Synthesis, anti-fungal activities and in silico studies of triazole/benzimidazole hybrid molecules

Abstract

A new series of triazole/benzimidazole hybrid molecules are synthesized using copper-catalyzed click reaction (CuAAC). All the newly synthesized compounds were well-characterized by analytical data. Most of the target compounds displayed potential anti-fungal activity against various Candida strains. In particular, compound 6a exhibited the highest antifungal activity against the tested Candida strains across all concentrations, highlighting its potential as a therapeutic agent, and the activity was supported by extensive in silico studies.