Development of a Core Outcomes Set for Peripheral Nerve Injury

Q3 Medicine

Journal of Hand Surgery Global Online Pub Date : 2025-05-21 DOI:10.1016/j.jhsg.2025.02.014

Christopher J. Dy MD, MPH , Alison L. Antes PhD , Heather L. Baltzer MD , Harvey Chim MD , Jana Dengler MD , Lisa Gfrerer MD , Scott H. Kozin MD , Yusha Katie Liu MD , Christine B. Novak DPT , Hollie A. Power MD , Nicholas Pulos MD , Jeffrey G. Stepan MD MSc

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Abstract

Purpose

The contemporary literature evaluating outcomes after peripheral nerve injury (PNI) does not rigorously and adequately address the domains (motor, sensory, function, and pain) experienced by patients. Our goal was to develop a core outcomes set (COS) to evaluate outcomes after PNI.

Methods

We adhered to recommended guidelines for COS development. Following a systematic review of the literature, we assembled a panel of experts and used a modified Delphi to assess the appropriateness of candidate measures to evaluate recovery after PNI. We convened 20 experts in PNI using two initial electronic surveys, one in-person meeting, and a final electronic survey. We arrived at consensus (≥70% of panelists) for required and recommended measures to evaluate outcomes after PNI.

Results

Our panel arrived at consensus for motor, sensory, function, and pain outcomes in patients after upper and lower extremity nerve injury. We designated the measures to use and the timing and administration of these measures.

Conclusions

We developed a COS that can be used by clinicians and researchers who evaluate patients with PNI. Our goal is to implement the COS in a unified manner, facilitating comparison in the literature as well as collaboration among centers.

Type of study/level of evidence

Diagnostic V.

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周围神经损伤核心结局集的发展

目的当前评价周围神经损伤（PNI）后预后的文献没有严格和充分地处理患者所经历的领域（运动、感觉、功能和疼痛）。我们的目标是建立一个核心结果集（COS）来评估PNI后的结果。方法我们遵循推荐的COS发展指南。在对文献进行系统回顾之后，我们召集了一个专家小组，并使用改进的德尔菲法来评估候选措施的适当性，以评估PNI后的恢复情况。我们召集了20位PNI专家，使用了两次初始电子调查、一次面对面会议和一次最终电子调查。我们达成共识（≥70%的小组成员），需要和推荐的措施来评估PNI后的结果。结果：我们的研究小组对上肢和下肢神经损伤后患者的运动、感觉、功能和疼痛结局达成了共识。我们指定了这些措施的使用以及这些措施的时机和管理。结论：我们开发了一套可用于临床医生和研究人员评估PNI患者的COS。我们的目标是以统一的方式实施COS，促进文献比较和中心之间的合作。研究类型/证据水平

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