A novel method to produce maximum ajoene and vinyl dithiin during garlic mustard oil macerate preparation

IF 2.1 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Sulfur Chemistry Pub Date : 2025-05-04 DOI:10.1080/17415993.2025.2459853

Joydeep Singha , Nipu Dutta , Jyoti Prasad Saikia

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引用次数: 0

Abstract

Garlic mustard oil macerate is a traditional medicine used as a nasal decongestant by the people of northeast India. In this study, a unique preparation technique that maximized the yield of organosulfur compounds in GMM was developed at the lowest preparation temperature and time duration compared to existing preparation methods. Liquid chromatography-mass spectrometry (LCMS), central composite design (CCD) and high-performance liquid chromatography (HPLC) were used for compound identification, experimental design, and quantification of the organosulfur compounds (OSCs), respectively. Through LCMS analysis, ajoene and 2-vinyl-4H-1,3-dithiin were detected as the major OSCs. CCD analysis suggested 17 experiments for HPLC analysis, after which the quantity of mustard oil and heating temperature were found to be the significant parameters for optimum OSCs formation. Based on this, the optimized conditions to maximize the yield of ajoene ((garlic: oil (1:2.00), 55.00°C, 4 $ \frac{1}{2} $

\frac{1}{2}

h)) and 2-vinyl-4H-1,3-dithiin ((garlic: oil (1:2.20), 77.51°C, 2 $ \frac{1}{2} $

\frac{1}{2}

h)) were achieved.

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在大蒜芥菜油浸渍制备过程中最大限度地生产烯和二硫乙烯的新方法

大蒜芥末油浸渍剂是一种传统药物，被印度东北部的人们用作鼻塞剂。在本研究中，与现有的制备方法相比，开发了一种独特的制备技术，在最低的制备温度和时间下，最大限度地提高了GMM中有机硫化合物的收率。采用液相色谱-质谱法（LCMS）、中心复合设计法（CCD）和高效液相色谱法（HPLC）对有机硫化合物（OSCs）进行化合物鉴定、实验设计和定量分析。通过LCMS分析，ajoene和2-乙烯基- 4h -1,3-二硫甙是主要的OSCs。CCD分析建议17个实验进行HPLC分析，之后发现芥菜油的量和加热温度是最优OSCs形成的重要参数。在此基础上，获得了产率最高的ajoene（大蒜：油（1:2.00），55.00°C, 4 $ $ frc {1}{2} $ 12 h）和2-乙烯基- 4h -1,3-二硫丁（大蒜：油（1:2.20），77.51°C, 2 $ $ frc {1}{2} $ 12 h）的优化条件。

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来源期刊

Journal of Sulfur Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.10

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science. Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.