Study on the effect of auxiliary airflow of the nasal spray Xhance on particle deposition in the nasal cavity

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL

Powder Technology Pub Date : 2025-05-15 DOI:10.1016/j.powtec.2025.121119

Hongxian Ren , Pengfei Jiang , Lixing Zhang , Zhenbo Tong , Ya Zhang , Aibing Yu , Baoming Ning , Langui Xie

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引用次数: 0

Abstract

The bidirectional nasal drug delivery method driven by respiration has better global and local drug delivery performance. However, research on bidirectional delivery technology is still insufficient, lacking systematic studies and mechanism analysis. This study reconstructed two real nasal cavity models and a drug delivery device. In vitro experiments and numerical simulations were conducted to explore the influence of auxiliary airflow on particle deposition within the nasal cavity. This study comprehensively examined how airflow rate, nasal anatomy, and particle size distribution influence particle deposition across various regions of the nasal cavity. The results indicate that in the absence of auxiliary airflow, particle deposition of the child and adult was concentrated in the region before the middle turbinate. As the auxiliary airflow increases, deposition in the nasal septum decreases, while deposition in the nasal turbinate region continues to increase. In the child's nasal cavity, the airflow distribution is primarily along the middle and inferior nasal passages, whereas in the adult, it is predominantly along the middle nasal passage. Under the influence of auxiliary airflow, particles smaller than 30 μm tend to deposit more easily in the nasal cavity of children, whereas particles smaller than 15 μm are more effectively deposited in the adult nasal cavity. 0–5 μm particles promote deposition in the olfactory region, while particles in the 5–10 μm range favor deposition in the middle nasal turbinate.

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鼻喷雾器辅助气流对鼻腔颗粒沉积影响的研究

呼吸驱动的鼻腔双向给药方式具有更好的全局和局部给药性能。然而，对双向输送技术的研究仍然不足，缺乏系统的研究和机理分析。本研究重建了两个真实的鼻腔模型和一个给药装置。通过体外实验和数值模拟，探讨辅助气流对鼻腔内颗粒沉积的影响。本研究全面考察了气流速率、鼻腔解剖结构和颗粒大小分布对鼻腔不同区域颗粒沉积的影响。结果表明，在没有辅助气流的情况下，儿童和成人的颗粒沉积集中在中鼻甲前区域。随着辅助气流的增加，鼻中隔的沉积减少，而鼻甲区的沉积继续增加。在儿童的鼻腔中，气流主要沿中、下鼻道分布，而在成人中，气流主要沿中鼻道分布。在辅助气流的影响下，小于30 μm的颗粒更容易在儿童鼻腔内沉积，而小于15 μm的颗粒更容易在成人鼻腔内沉积。0 ~ 5 μm颗粒促进嗅觉区沉积，5 ~ 10 μm颗粒有利于鼻甲中部沉积。

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.