Gut microbiota-mediated GPCR drug metabolism affects downstream pharmacological activity

IF 19.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature chemistry Pub Date : 2025-05-21 DOI:10.1038/s41557-025-01840-w

Amy K. Bracken, Pamela V. Chang

引用次数: 0

Abstract

G-protein-coupled receptors (GPCRs) are linked to a plethora of human diseases, but the efficacy of drugs that target GPCRs often varies between patients. Now, a link has been established between the gut microbiome and GPCR drug metabolism, in which the identities of the microbes directly influence the metabolites formed and the host drug response.

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肠道菌群介导的GPCR药物代谢影响下游药理活性

g蛋白偶联受体（gpcr）与许多人类疾病有关，但针对gpcr的药物的疗效往往因患者而异。现在，肠道微生物组与GPCR药物代谢之间已经建立了联系，其中微生物的身份直接影响代谢产物的形成和宿主的药物反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemistry 化学-化学综合

CiteScore

29.60

自引率

1.40%

发文量

226

审稿时长

1.7 months

期刊介绍： Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry. The journal also features interdisciplinary research at the interface of chemistry with biology, materials science, nanotechnology, and physics. Manuscripts detailing such multidisciplinary work are encouraged, as long as the central theme pertains to chemistry. Aside from primary research, Nature Chemistry publishes review articles, news and views, research highlights from other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical landscape. It also addresses crucial issues related to education, funding, policy, intellectual property, and the societal impact of chemistry. Nature Chemistry is dedicated to ensuring the highest standards of original research through a fair and rigorous review process. It offers authors maximum visibility for their papers, access to a broad readership, exceptional copy editing and production standards, rapid publication, and independence from academic societies and other vested interests. Overall, Nature Chemistry aims to be the authoritative voice of the global chemical community.