Hypoxia-responsive liquid metal-containing nanomaterial for cancer phototheranostics

IF 5.8 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Pub Date : 2025-05-21 DOI:10.1039/d5nr01761k

Wenlong Zhang, Heting Li, Bing Wu, Qinguan Zhang, Yaning He

引用次数: 0

Abstract

In this communication, we introduce a hypoxia-responsive liquid metal-containing nanomaterial, referred to as LMNPs/HS-β-CD/TPE-2NHCOO-azo-TEG complex, for cancer phototheranostics. This novel nanomaterial exhibits several intriguing properties, and its features rest with a hypoxia-responsive azobenzene moiety, an aggregation-induced emission fluorogen, and liquid metal nanoparticles (LMNPs). The aggregation-induced emission structure within the probe enables fluorescence imaging, and the released LMNPs can elicit tumor cell death through photothermal effects under near-infrared laser irradiation, thereby enabling integrated diagnosis and treatment.

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用于癌症光疗的低氧响应液态含金属纳米材料

在本文中，我们介绍了一种用于癌症光疗的低氧响应液态含金属纳米材料，称为LMNPs/HS-β-CD/ tpe - 2nhco -偶氮- teg配合物。这种新型纳米材料表现出几个有趣的特性，其特征在于低氧响应偶氮苯部分、聚集诱导的发射氟化物和液态金属纳米颗粒（LMNPs）。探针内部聚集诱导的发射结构可以实现荧光成像，释放的LMNPs可以在近红外激光照射下通过光热效应诱导肿瘤细胞死亡，从而实现一体化诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.