Frontiers in Single-Molecule Junction Detection: A Review of Recent Innovations and Breakthroughs.

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2025-05-20 DOI:10.1021/acs.langmuir.5c00270

Dingling Zhuang,Dongdong Wang,Jizhe Xu,Ziyun Tang,Juan Joon Ching,Tau Chuan Ling,Xiaohui Li,Wenjing Hong

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引用次数: 0

Abstract

Single-molecule junction techniques offer powerful tools for studying physical and chemical properties at the single-molecule level, while enabling groundbreaking advances in ultrasensitive sensing. This review encapsulates the latest progress made in tracking chemical reactions and intermolecular interactions by employing single-molecule junction techniques. Additionally, we explore their practical applications in detection and sensing of trace chemical substances and biomolecules. Single-molecule electrical measurements, such as mechanically controllable break junctions (MCBJs), scanning tunneling microscopy break junctions (STM-BJs), and graphene-molecule-graphene single-molecule junctions (GMG-SMJ), exhibit exceptional sensitivity and resolution. These techniques allow for precise control and detection at the molecular scale, providing powerful tools for research across disciplines such as chemistry, biology, and physics while also driving new discoveries and advancements in related fields. Furthermore, we highlight the applications of single-molecule junction-based sensing techniques in identifying small molecules and ions in various media, thus contributing noteworthy insights into the design of ultrasensitive single-molecule sensors.

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单分子结检测前沿：近期创新与突破综述

单分子结技术为研究单分子水平的物理和化学性质提供了强大的工具，同时在超灵敏传感方面取得了突破性进展。本文综述了利用单分子结技术跟踪化学反应和分子间相互作用的最新进展。此外，我们还探讨了它们在痕量化学物质和生物分子的检测和传感中的实际应用。单分子电测量，如机械可控断结（MCBJs）、扫描隧道显微镜断结（STM-BJs）和石墨烯-分子-石墨烯单分子结（GMG-SMJ），表现出卓越的灵敏度和分辨率。这些技术可以在分子尺度上进行精确的控制和检测，为化学、生物学和物理学等跨学科研究提供了强大的工具，同时也推动了相关领域的新发现和进步。此外，我们强调了基于单分子结的传感技术在识别各种介质中的小分子和离子方面的应用，从而为超灵敏单分子传感器的设计提供了值得注意的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).