Demystifying Glycemic Variability in GDM Pregnancies: A Cross-Sectional Observational Study.

IF 0.7 Q4 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynecology of India Pub Date : 2025-04-01 Epub Date: 2024-06-27 DOI:10.1007/s13224-024-01992-8

Anamika Baghel, Aruna Nigam, Nidhi Gupta

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Abstract

Aim: To study glycemic variability (GV) and 24-h ambulatory glucose profile (AGP) in gestational diabetes mellitus (GDM) patients who were apparently controlled on drugs and their correlation with fetomaternal outcomes.

Methodology: In this cross-sectional observational study, 40 gestational diabetic pregnancies on pharmacotherapy were recruited. Flash glucose monitor was used to record AGP between 32 and 36 weeks of gestation. A total of 600 patient days with 58,600 glucose values were analyzed.

Results: Variables of GV: Mean amplitude of glycemic excursion (p = 0.001), standard deviation (p = 0.001), Continuous Overall Net Glycemic Action (p = 0.002) and High Blood Glucose Index (p = 0.001) were significantly high in GDM group when compared to normoglycemic patients and these were well correlated with poor fetomaternal outcome in this group. Time in range was also significantly altered in GDM group. (p < 0.001).

Conclusion: High GV and time in range are the important parameters which get altered in GDM pregnancies despite apparent control of blood glucose, and this can be a reason of adverse fetomaternal outcomes in these pregnancies.

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揭开妊娠糖尿病患者血糖变异性的神秘面纱：一项横断面观察研究。

目的：探讨药物控制妊娠期糖尿病（GDM）患者的血糖变异性（GV）和24小时动态血糖谱（AGP）与胎儿结局的关系。方法：在这项横断面观察性研究中，招募了40名接受药物治疗的妊娠期糖尿病孕妇。妊娠32 ~ 36周时，采用瞬时血糖仪记录AGP。总共分析了600个患者日的58,600个血糖值。结果：GV变量：血糖漂移平均幅度（p = 0.001）、标准差（p = 0.001）、持续总体净血糖作用（p = 0.002）和高血糖指数（p = 0.001）与血糖正常患者相比，GDM组的血糖漂移平均幅度（p = 0.001）显著升高，且与该组不良的胎儿结局密切相关。GDM组在范围内的时间也有明显改变。结论：高GV和范围时间是妊娠期GDM患者在血糖得到明显控制的情况下发生改变的重要参数，这可能是妊娠期GDM患者不良结局的原因之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynecology of India OBSTETRICS & GYNECOLOGY-

CiteScore

1.30

自引率

0.00%

发文量

124

期刊介绍： Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: · Original Article· Case Report · Instrumentation and Techniques · Short Commentary · Correspondence (Letter to the Editor) · Pictorial Essay