{"title":"Intrauterine Transfusion for Fetal Anemia: An 8-Year Experience from a Tertiary Care Center.","authors":"Zaneta Dias, Rinshi Abid Elayedatt, Anupama Karthik, Vivek Krishnan","doi":"10.1007/s13224-024-01985-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim and background: </strong>To study the procedure-related complications and outcomes of intrauterine transfusion (IUT) in fetal anemia.</p><p><strong>Methods: </strong>A single tertiary care center, retrospective observational study of severe fetal anemia treated with IUT. The influence of gestational age (GA) at transfusion, hydrops, and route of transfusion on procedure-related complications were studied and the postnatal outcomes were recorded.</p><p><strong>Results: </strong> A total of 59 IUT's were performed in 33 anemic fetuses. Rh isoimmunization (30/33) was the most common indication in 90.9%. The mean GA of fetuses who developed procedural complications was 3 weeks earlier (Mean: 26 weeks) than in those in whom the procedure was uneventful (Mean: 29.8 weeks). The umbilical vein (UV) was the main route of entry in 86.4% of fetuses. All hydropic fetuses in the study needed an earlier transfusion than the nonhydropic ones. A total of six procedural complications were observed which varied from mild bradycardia (<i>n</i> = 1), intraperitoneal spill (<i>n</i> = 1), and preterm premature rupture of membranes (PPROM) (<i>n</i> = 1) to IUD (<i>n</i> = 3) of which with 2 IUD's, one PPROM and one intraperitoneal spill were seen in hydropic fetuses. The median age of delivery after IUT was 35 weeks. All neonates needed intensive phototherapy, 72% needed post-delivery transfusion, and 30% transfusion for late neonatal anemia.</p><p><strong>Conclusion: </strong>Early GA of transfusion and the presence of hydrops increased procedure-related adverse events. Small sample size and confounding factors like hydrops and early gestational age at transfusions made it difficult to comment on the influence of route on procedure-related complications.</p>","PeriodicalId":51563,"journal":{"name":"Journal of Obstetrics and Gynecology of India","volume":"75 Suppl 1","pages":"327-332"},"PeriodicalIF":0.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085450/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetrics and Gynecology of India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13224-024-01985-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim and background: To study the procedure-related complications and outcomes of intrauterine transfusion (IUT) in fetal anemia.
Methods: A single tertiary care center, retrospective observational study of severe fetal anemia treated with IUT. The influence of gestational age (GA) at transfusion, hydrops, and route of transfusion on procedure-related complications were studied and the postnatal outcomes were recorded.
Results: A total of 59 IUT's were performed in 33 anemic fetuses. Rh isoimmunization (30/33) was the most common indication in 90.9%. The mean GA of fetuses who developed procedural complications was 3 weeks earlier (Mean: 26 weeks) than in those in whom the procedure was uneventful (Mean: 29.8 weeks). The umbilical vein (UV) was the main route of entry in 86.4% of fetuses. All hydropic fetuses in the study needed an earlier transfusion than the nonhydropic ones. A total of six procedural complications were observed which varied from mild bradycardia (n = 1), intraperitoneal spill (n = 1), and preterm premature rupture of membranes (PPROM) (n = 1) to IUD (n = 3) of which with 2 IUD's, one PPROM and one intraperitoneal spill were seen in hydropic fetuses. The median age of delivery after IUT was 35 weeks. All neonates needed intensive phototherapy, 72% needed post-delivery transfusion, and 30% transfusion for late neonatal anemia.
Conclusion: Early GA of transfusion and the presence of hydrops increased procedure-related adverse events. Small sample size and confounding factors like hydrops and early gestational age at transfusions made it difficult to comment on the influence of route on procedure-related complications.
期刊介绍:
Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: · Original Article· Case Report · Instrumentation and Techniques · Short Commentary · Correspondence (Letter to the Editor) · Pictorial Essay