Intrauterine Transfusion for Fetal Anemia: An 8-Year Experience from a Tertiary Care Center.

IF 0.7 Q4 OBSTETRICS & GYNECOLOGY
Zaneta Dias, Rinshi Abid Elayedatt, Anupama Karthik, Vivek Krishnan
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Abstract

Aim and background: To study the procedure-related complications and outcomes of intrauterine transfusion (IUT) in fetal anemia.

Methods: A single tertiary care center, retrospective observational study of severe fetal anemia treated with IUT. The influence of gestational age (GA) at transfusion, hydrops, and route of transfusion on procedure-related complications were studied and the postnatal outcomes were recorded.

Results:  A total of 59 IUT's were performed in 33 anemic fetuses. Rh isoimmunization (30/33) was the most common indication in 90.9%. The mean GA of fetuses who developed procedural complications was 3 weeks earlier (Mean: 26 weeks) than in those in whom the procedure was uneventful (Mean: 29.8 weeks). The umbilical vein (UV) was the main route of entry in 86.4% of fetuses. All hydropic fetuses in the study needed an earlier transfusion than the nonhydropic ones. A total of six procedural complications were observed which varied from mild bradycardia (n = 1), intraperitoneal spill (n = 1), and preterm premature rupture of membranes (PPROM) (n = 1) to IUD (n = 3) of which with 2 IUD's, one PPROM and one intraperitoneal spill were seen in hydropic fetuses. The median age of delivery after IUT was 35 weeks. All neonates needed intensive phototherapy, 72% needed post-delivery transfusion, and 30% transfusion for late neonatal anemia.

Conclusion: Early GA of transfusion and the presence of hydrops increased procedure-related adverse events. Small sample size and confounding factors like hydrops and early gestational age at transfusions made it difficult to comment on the influence of route on procedure-related complications.

子宫内输血治疗胎儿贫血:一家三级医疗中心8年的经验。
目的与背景:探讨宫内输注治疗胎儿贫血的手术相关并发症及预后。方法:在单一三级保健中心,对IUT治疗重度胎儿贫血进行回顾性观察研究。研究了输血时胎龄(GA)、积液和输血途径对手术相关并发症的影响,并记录了产后结局。结果:33例贫血胎儿共行59例IUT。Rh等免疫(30/33)是最常见的适应症,占90.9%。发生手术并发症的胎儿的平均GA比手术无并发症的胎儿(平均29.8周)早3周(平均26周)。86.4%的胎儿以脐静脉(UV)为主要进入途径。研究中所有积水胎儿都需要比非积水胎儿更早的输血。共观察到6例手术并发症,从轻度心动过缓(n = 1)、腹膜溢漏(n = 1)和早产早破膜(PPROM) (n = 1)到宫内节育器(n = 3),其中2个宫内节育器、1个PPROM和1个腹膜溢漏在积水胎儿中可见。IUT后的中位分娩年龄为35周。所有新生儿都需要强化光疗,72%的新生儿需要产后输血,30%的新生儿晚期贫血需要输血。结论:早期输血GA和积液的存在增加了手术相关的不良事件。样本量小,再加上输血时积液和胎龄早等混杂因素,很难评价输血途径对手术相关并发症的影响。
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
124
期刊介绍: Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: ·         Original Article·         Case Report ·         Instrumentation and Techniques ·         Short Commentary ·         Correspondence (Letter to the Editor) ·         Pictorial Essay
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