Immunohistochemical Diversity of Endometrial Carcinoma and Their Implications in Prognosis: A Prospective Clinicopathological Study in a Tertiary Care Hospital of Eastern India.

IF 0.7 Q4 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynecology of India Pub Date : 2025-04-01 Epub Date: 2024-08-31 DOI:10.1007/s13224-024-02046-9

Rajashree Pradhan, Ranu Roy Biswas, Sajeeb Mondal, Upasana Mukherjee

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引用次数: 0

Abstract

Background: Endometrial cancer is the sixth most common cancer in women worldwide with gradually increasing incidence and mortality rate. The most recent classification of endometrial carcinoma (EC) with diagnostic flowchart includes both immunohistochemical and molecular markers for prognostic purpose and better management of endometrial cancer. In this study, we want to analyze various immunohistochemical (IHC) markers in EC and their prognostic significance.

Methods: This was a prospective study conducted from August 2016 to February 2024. We studied 168 cases of EC for histopathological subtypes, grading and various IHC markers such as Estrogen Receptor (ER), Her 2 Neu, Cytokeratin 5/6, Epithelial Membrane Antigen (EMA) and p53.

Results: In our study, most common histological subtype was endometrioid (132) followed by serous (17), mucinous (8), clear cell (7) and carcinosarcoma (4). ER expression was mostly seen in endometrioid type. Loss of ER expression and Her 2 expression along with p53 over expression was not only associated with high grade EC but also with advanced clinical stage and lymph node metastasis.

Conclusion: Immunohistochemical markers play a definite role in risk stratification and specific individual oriented therapy in endometrial cancer patients.

Supplementary information: The online version contains supplementary material available at 10.1007/s13224-024-02046-9.

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子宫内膜癌的免疫组织化学多样性及其对预后的影响：印度东部一家三级医院的前瞻性临床病理研究。

背景：子宫内膜癌是全球第六大最常见的女性癌症，其发病率和死亡率逐渐上升。子宫内膜癌（EC）的最新分类和诊断流程图包括免疫组织化学和分子标记，用于预后目的和子宫内膜癌的更好管理。在这项研究中，我们想分析各种免疫组化（IHC）标志物在EC及其预后意义。方法：前瞻性研究于2016年8月至2024年2月进行。我们研究了168例EC的组织病理学亚型、分级和各种免疫组化标志物，如雌激素受体（ER）、Her 2 Neu、细胞角蛋白5/6、上皮膜抗原（EMA）和p53。结果：在我们的研究中，最常见的组织学亚型是子宫内膜样（132），其次是浆液性（17）、粘液性(8)、透明细胞性(7)和癌肉瘤(4)。ER表达多见于子宫内膜样型。ER和Her 2表达缺失以及p53过表达不仅与高级别EC相关，而且与晚期临床分期和淋巴结转移有关。结论：免疫组织化学标志物在子宫内膜癌患者的危险分层和特异性个体化治疗中具有明确的作用。补充信息：在线版本包含补充资料，下载地址：10.1007/s13224-024-02046-9。

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来源期刊

Journal of Obstetrics and Gynecology of India OBSTETRICS & GYNECOLOGY-

CiteScore

1.30

自引率

0.00%

发文量

124

期刊介绍： Journal of Obstetrics and Gynecology of India (JOGI) is the official journal of the Federation of Obstetrics and Gynecology Societies of India (FOGSI). This is a peer- reviewed journal and features articles pertaining to the field of obstetrics and gynecology. The Journal is published six times a year on a bimonthly basis. Articles contributed by clinicians involved in patient care and research, and basic science researchers are considered. It publishes clinical and basic research of all aspects of obstetrics and gynecology, community obstetrics and family welfare and subspecialty subjects including gynecological endoscopy, infertility, oncology and ultrasonography, provided they have scientific merit and represent an important advance in knowledge. The journal believes in diversity and welcomes and encourages relevant contributions from world over. The types of articles published are: · Original Article· Case Report · Instrumentation and Techniques · Short Commentary · Correspondence (Letter to the Editor) · Pictorial Essay