Zinc as an adjunct in radiation-based therapies: Evidences of radioprotection and mechanistic insights.

IF 1.9 Q3 NUTRITION & DIETETICS
Sachin Tayal, Navpreet Kaur, Tanzeer Kaur, Vijayta D Chadha
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Abstract

BackgroundRadiation-based therapies are a progressive modality for managing life-threatening diseases such as cancer. However, these treatments often inflict damage on non-target tissues, necessitating the development of effective radioprotective agents. Zinc, known for its diversified role under various pathological conditions, has emerged as a potential protective agent against radiation-induced injuries due to its antioxidant, anti-inflammatory and immune-regulating properties.AimThis review aims to evaluate the potential of zinc in mitigating the adverse effects associated with radiation-based therapies, focusing on its protective role in normal tissue injury.MethodsA comprehensive literature review was conducted using multiple databases, including PubMed, NCBI, SciFinder, Google Scholar and Science Direct. Relevant studies assessing the radioprotective effects of zinc were identified and analysed to summarise its efficacy and potential benefits in radiation therapy.ResultsThe review highlights the beneficial effects of zinc in managing radiation-induced adverse effects, such as oral mucositis, skin injury, dermatitis, xerostomia, dysgeusia, dysosmia, bone marrow regeneration and oxidative stress reduction. Zinc's role as an antioxidant and anti-inflammatory agent, along with its ability to regulate immune system homeostasis, underpins these protective effects.ConclusionsZinc shows promising potential as a radioprotective agent in mitigating the adverse effects of radiation-based therapies. Despite the positive preclinical and clinical findings, further randomised trials with larger sample sizes and rigorous methodologies are needed to confirm zinc's efficacy. Additionally, further research is warranted to explore zinc's potential in addressing other radiation-induced events, ultimately contributing to improved patient care during radiation therapy.

锌在放射治疗中的辅助作用:放射防护的证据和机制见解。
背景:放射疗法是治疗癌症等危及生命的疾病的一种渐进方式。然而,这些治疗通常会对非靶组织造成损伤,因此需要开发有效的放射防护剂。锌因其抗氧化、抗炎和免疫调节的特性,在各种病理条件下具有多种作用,已成为抗辐射损伤的潜在保护剂。目的本综述旨在评估锌在减轻放射治疗相关不良反应方面的潜力,重点关注其在正常组织损伤中的保护作用。方法采用PubMed、NCBI、SciFinder、b谷歌Scholar、Science Direct等数据库进行文献综述。对评价锌的放射防护作用的相关研究进行了鉴定和分析,总结了锌在放射治疗中的疗效和潜在益处。结果锌在处理口腔黏膜炎、皮肤损伤、皮炎、口干、嗅觉障碍、骨髓再生和氧化应激等放射性不良反应中的有益作用。锌作为抗氧化剂和抗炎剂的作用,以及它调节免疫系统稳态的能力,巩固了这些保护作用。结论锌作为一种放射防护剂在减轻放射治疗的不良反应方面具有良好的潜力。尽管有积极的临床前和临床研究结果,但需要进一步进行更大样本量的随机试验和严格的方法来证实锌的功效。此外,进一步的研究需要探索锌在解决其他辐射诱发事件方面的潜力,最终有助于改善放射治疗期间的患者护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrition and health
Nutrition and health Medicine-Medicine (miscellaneous)
CiteScore
3.50
自引率
0.00%
发文量
160
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