A comprehensive overview of fish envenomation and venom toxicity in Brazil.

IF 1.8 3区 医学 Q4 TOXICOLOGY
Mônica Lopes-Ferreira, Felipe Justiniano Pinto, Yasmin Stefanie Oliveira Costa, Alessa Aparecida Burgarelli, Louise Lene Gomes Lima, Bibiana da Silva Marques, Carla Simone Seibert, Elineide Eugenio Marques, Patrícia Charvet, Vidal Haddad, João Gabriel Dos Santos Rosa, Geonildo Rodrigo Disner, Carla Lima
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引用次数: 0

Abstract

Background: Brazilian waters are home to various venomous fish species, each with its unique venom composition. Although common, envenomation cases are largely underreported, leading to a lack of public health policies for prevention and treatment. Some of the most clinically relevant fish in Brazil include the stingray Potamotrygon orbignyi, the toadfish Thalassophryne nattereri, the scorpionfish Scorpaena plumieri, and the catfish Pseudoplatystoma fasciatum and Cathorops spixii.

Methods: We comprehensively searched reports about accidents involving venomous fish in Brazil and compared the toxic activities of some medically relevant species.

Results: From the biochemical and toxicological evaluation, we found that venoms show a hierarchy in the ability to induce local toxic effects in mice, probably related to the venom compound diversity with species-specific toxins. T. nattereri venom presents greater toxicity, causing more severe local responses than that of P. orbignyi, C. spixii, and P. fasciatum, which cause moderate reactions. The S. plumieri venom induced only a moderate level of edema and could not cause nociception or necrosis. These results highlight that envenomation by P. orbigny, C. spixii, and S. plumieri is marked by proteins with intense hemolytic/proteolytic and phospholipase activity. On the other hand, T. nattereri and P. fasciatum offered a broader panel of new toxin families.

Conclusion: Knowledge of fish venom biochemical and toxicological activities is crucial to antivenom therapy development and helps endorse the study of venomous fish and their impact on the public health system.

巴西鱼类中毒和毒液毒性的全面概述。
背景:巴西水域是各种有毒鱼类的家园,每一种都有其独特的毒液成分。虽然常见,但中毒病例在很大程度上被低估,导致缺乏预防和治疗的公共卫生政策。在巴西最具临床意义的鱼类包括黄貂鱼poamotrygon orbignyi,海蟾蜍鱼Thalassophryne nattereri,蝎子鱼Scorpaena plumieri,以及鲶鱼Pseudoplatystoma fasciatum和Cathorops spixii。方法:我们综合检索了巴西有关有毒鱼类事故的报道,并比较了一些医学相关物种的毒性活性。结果:从生物化学和毒理学评价来看,我们发现毒液对小鼠的局部毒性作用表现出等级性,这可能与毒液与物种特异性毒素的化合物多样性有关。纳特纳氏绦虫毒液毒性更大,引起的局部反应比奥比尼弧菌、螺旋体弧菌和筋膜弧菌更严重,后者引起的反应比较温和。该毒液仅引起中度水肿,不会引起痛觉或坏死。这些结果表明,弓形假单胞菌、螺旋体假单胞菌和羽绒假单胞菌的毒杀以具有强烈溶血/蛋白水解活性和磷脂酶活性的蛋白质为标志。另一方面,天麻和筋膜棘提供了更广泛的新毒素科。结论:了解鱼毒的生化和毒理学活性对抗蛇毒治疗的发展至关重要,并有助于支持有毒鱼类及其对公共卫生系统的影响的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
39
审稿时长
6-12 weeks
期刊介绍: Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.
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