Host-parasite interplay within a phoronid-microsporidia system: anti-parasitic defense in Lophophorata

Abstract

Microsporidia (Opisthokonta: Rozellomycota: Microsporidia) are ubiquitous intracellular parasites infecting representatives of all major taxonomic groups of Animalia, from protozoans to mammals, and infecting marine, freshwater, and terrestrial hosts. A representative of the phylum Phoronida was recently added to the list of microsporidian hosts. Only one species Microsporidium phoronidi, a parasite of Phoronis embryolabi, has been recently described. The paper presents further study of this host-parasite system, specifically, the observation of an efficient anti-microsporidial defense reaction in a phoronid host, and a unique mechanism of clearing the host of infection. This defense reaction results in encapsulation of infected cells and subsequent releasing of the capsules through excretory ducts of metanephridia, together with larvae, which regularly leave the mother organism this way. We hypothesize that by encapsulation, phoronids destroy most of parasites, block spread of the infection throughout the body, and prevent horizontal transmission. At the same time, microsporidia that develop in vasoperitoneal tissue that nourish maturing oocytes and embryos, likely overcome the host defense by sporadic or regular infection of embryos. As a result, the parasite secures its persistence in host populations by vertical transmission, which, in turn, benefits evolving less pathogenic forms. Overall, such elaborated and well-balanced phoronid host–microsporidia parasite interactions may suggest long history of co-existence and deserve further studies. New data extend our knowledge about parasite-host interactions and immune response in Lophophorata.