A Study on Prognostic Risk Factors of Cervical Spondylotic Myelopathy.

IF 1.4 4区医学 Q4 CLINICAL NEUROLOGY

Journal of Korean Neurosurgical Society Pub Date : 2025-05-20 DOI:10.3340/jkns.2025.0021

Zihan Zhou, Yunxin Su, Yuqi Shao, Jiayun Liu, Xincan Wu, Peng Gao, Tao Qin, Kaixiao Xue, Guoyong Yin, Jian Chen

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引用次数: 0

Abstract

Objective: To identify the risk factors that influence the prognosis of patients with cervical spondylotic myelopathy (CSM).

Methods: Clinical data were collected from 158 CSM patients treated between January 2023 and January 2024 at a tertiary medical center. The data were retrospectively analyzed, with a one-year follow-up. Based on the Japanese Orthopaedic Association score, patients were categorized into good and poor recovery groups. Clinical characteristics, laboratory indices, and imaging findings were compared between the groups, and risk factors affecting CSM prognosis were identified.

Results: In a multivariable analysis, age, symptom duration, preoperative Japanese Orthopaedic Association (JOA) score, spinal cord compression ratio, Treg cell count, the number of surgical levels and diabetes history were identified as significant predictors of postoperative outcomes. Interestingly, Treg cell counts showed a novel positive correlation with improvement rates (P < 0.001), suggesting their potential role in spinal cord recovery after surgery.

Conclusion: These findings underscore the prognostic relevance of clinical and immunological factors for predicting surgical outcomes in CSM. The observed association between peripheral Treg counts and recovery rates reveals new insights into the immunological mechanisms underlying CSM prognosis, suggesting potential targets for personalized treatment strategies.

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脊髓型颈椎病预后危险因素的研究。

目的：探讨影响脊髓型颈椎病（CSM）患者预后的危险因素。方法：收集某三级医疗中心2023年1月至2024年1月收治的158例CSM患者的临床资料。对数据进行回顾性分析，随访一年。根据日本骨科协会评分，将患者分为恢复良好组和恢复不良组。比较两组患者的临床特征、实验室指标及影像学表现，并分析影响CSM预后的危险因素。结果：在一项多变量分析中，年龄、症状持续时间、术前日本骨科协会（JOA）评分、脊髓压缩比、Treg细胞计数、手术水平次数和糖尿病史被确定为术后预后的重要预测因素。有趣的是，Treg细胞计数与改善率呈新的正相关（P < 0.001），表明它们在脊髓术后恢复中的潜在作用。结论：这些发现强调了临床和免疫因素对预测CSM手术结果的预后相关性。观察到的外周Treg计数和恢复率之间的关联揭示了CSM预后的免疫学机制的新见解，为个性化治疗策略提供了潜在的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Korean Neurosurgical Society 医学-临床神经学

CiteScore

2.90

自引率

6.20%

发文量

109

审稿时长

3-8 weeks

期刊介绍： The Journal of Korean Neurosurgical Society (J Korean Neurosurg Soc) is the official journal of the Korean Neurosurgical Society, and published bimonthly (1st day of January, March, May, July, September, and November). It launched in October 31, 1972 with Volume 1 and Number 1. J Korean Neurosurg Soc aims to allow neurosurgeons from around the world to enrich their knowledge of patient management, education, and clinical or experimental research, and hence their professionalism. This journal publishes Laboratory Investigations, Clinical Articles, Review Articles, Case Reports, Technical Notes, and Letters to the Editor. Our field of interest involves clinical neurosurgery (cerebrovascular disease, neuro-oncology, skull base neurosurgery, spine, pediatric neurosurgery, functional neurosurgery, epilepsy, neuro-trauma, and peripheral nerve disease) and laboratory work in neuroscience.