Polymeric hollow fibers for encapsulating Eucalyptus galbie essential oil with decongestant potential and physicochemical study.

Abstract

Eucalyptus species are known for their decongestant and antimicrobial properties, mainly due to their essential oil. However, significant challenges persist in maintaining the stability and durability of the essential oils' effectiveness. This study examines the use of polymeric hollow fibers for encapsulating Eucalyptus essential oil (EE) to improve its stability and effectiveness in treating nasal congestion. The EE was obtained by hydro-distillation method, and analyzed using gas chromatography-mass spectrometry (GC-MS). A dialysis cartridge containing polysulfone hollow fibers was used to load the EE, and their permeability, morphology, and stability were assessed. Fourier-transform infrared spectroscopy (FT-IR) and headspace sampling with gas chromatography-flame ionization detection (GC-FID) were employed to monitor EE release and the stability of EE-loaded hollow fibers. GC/MS analysis identified 20 major components with 1,8-cineole being the predominant compound at 59.32%. Physicochemical characterization of hollow fibers revealed complete permeability to EE. FT-IR spectra suggested potential interactions between EE and the fibers. Release studies indicated that over 80% of EE was released from the fibers within 180 min. Headspace analysis confirmed the presence and stability of 1,8-cineole in the loaded fibers. The stability test demonstrated no significant changes in the EE-loaded fibers over 6 days. This study indicated that the capillary properties of the EE-loaded hollow fibers facilitate oil loading, and headspace sampling provides a more efficient analysis. The successful and stable release of EE from the fibers, highlights the potential of hollow fibers for controlled drug delivery. However, conducting more accurate experiments can help deduce more logical results.