Polymeric hollow fibers for encapsulating Eucalyptus galbie essential oil with decongestant potential and physicochemical study.

IF 3.1 4区 医学 Q2 BIOPHYSICS
Reyhane Shojaei, Mehdi Ansari, Neda Mohamadi, Fariba Sharififar
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Abstract

Eucalyptus species are known for their decongestant and antimicrobial properties, mainly due to their essential oil. However, significant challenges persist in maintaining the stability and durability of the essential oils' effectiveness. This study examines the use of polymeric hollow fibers for encapsulating Eucalyptus essential oil (EE) to improve its stability and effectiveness in treating nasal congestion. The EE was obtained by hydro-distillation method, and analyzed using gas chromatography-mass spectrometry (GC-MS). A dialysis cartridge containing polysulfone hollow fibers was used to load the EE, and their permeability, morphology, and stability were assessed. Fourier-transform infrared spectroscopy (FT-IR) and headspace sampling with gas chromatography-flame ionization detection (GC-FID) were employed to monitor EE release and the stability of EE-loaded hollow fibers. GC/MS analysis identified 20 major components with 1,8-cineole being the predominant compound at 59.32%. Physicochemical characterization of hollow fibers revealed complete permeability to EE. FT-IR spectra suggested potential interactions between EE and the fibers. Release studies indicated that over 80% of EE was released from the fibers within 180 min. Headspace analysis confirmed the presence and stability of 1,8-cineole in the loaded fibers. The stability test demonstrated no significant changes in the EE-loaded fibers over 6 days. This study indicated that the capillary properties of the EE-loaded hollow fibers facilitate oil loading, and headspace sampling provides a more efficient analysis. The successful and stable release of EE from the fibers, highlights the potential of hollow fibers for controlled drug delivery. However, conducting more accurate experiments can help deduce more logical results.

具有减充血潜能的加利比桉精油包封用聚合物中空纤维及其理化研究。
桉树以其减充血剂和抗菌特性而闻名,主要是由于它们的精油。然而,在保持精油有效性的稳定性和持久性方面仍然存在重大挑战。本研究探讨了聚合物中空纤维包封桉树精油(EE)以提高其治疗鼻塞的稳定性和有效性。采用水蒸气蒸馏法获得EE,并采用气相色谱-质谱联用(GC-MS)进行分析。使用含有聚砜中空纤维的透析盒来加载EE,并评估其渗透性,形态和稳定性。采用傅里叶变换红外光谱(FT-IR)和顶空采样-气相色谱-火焰离子化检测(GC-FID)技术监测载EE中空纤维的释放和稳定性。GC/MS分析鉴定出20种主要成分,其中以1,8-桉叶脑为主,占59.32%。中空纤维的理化性质表明其对EE具有完全的渗透性。FT-IR光谱显示了EE和纤维之间潜在的相互作用。释放研究表明,超过80%的EE在180分钟内从纤维中释放出来。顶空分析证实了1,8-桉树脑在负载纤维中的存在和稳定性。稳定性测试表明,在6天内,ee负载纤维没有显着变化。该研究表明,载e中空纤维的毛细特性有利于载油,顶空取样提供了更有效的分析。从纤维中成功和稳定地释放EE,突出了中空纤维在控制药物输送方面的潜力。然而,进行更精确的实验可以帮助推断出更合乎逻辑的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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