The association between number of retrieved lymph nodes and survival in gastric cancer surgery: a Dutch population-based study.

IF 1.8 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Digestive Surgery Pub Date : 2025-05-19 DOI:10.1159/000546436

Weikeat K Ooi, Sander J M van Hootegem, Low Kuan Yean, Leonie R van der Werf, Pieter Christiaan van der Sluis, S M Lagarde, Bas P L Wijnhoven

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引用次数: 0

Abstract

Background: This study aimed to evaluate whether the retrieval of 15 or more lymph nodes (LN) during gastrectomy for cancer is associated with better survival and more accurate pathological staging.

Methods: Patients that underwent gastrectomy between 2011 and 2016 were reviewed from the Dutch Upper Gastrointestinal Cancer Audit. Patients with <15 and ≥15 LN retrieved were compared after propensity-score matching based on patient and tumor characteristics. The primary endpoint was 3-year overall survival.

Results: A total of 2047 patients were included in the study. After propensity score matching, 522 patients with ≥15 LNs were matched to 522 patients with <15 LNs. There was no statistically significant difference in overall survival between both groups, with 3-year survival rates of 56% versus 59%, respectively. Patients with ≥15 LNs had a more advanced pN-category. While median survival was higher for patients with ≥15 LNs versus <15 LNs in the subgroups pN2, pN3a, and pN3b, no statistically significant differences were found. Similar results were found in the propensity score matched cohort using 23 LNs as cut-off.

Conclusions: ≥15 LNs retrieved during gastrectomy for cancer was associated with higher pN-stage, likely as a result of stage migration. Three-year overall survival was comparable for patients with ≥15 LNs and patients with <15 LNs retrieved.

查看原文本刊更多论文

胃癌手术中淋巴结数量与生存率的关系：一项基于荷兰人群的研究。

背景：本研究旨在评估胃癌切除术期间切除15个或更多淋巴结（LN）是否与更好的生存率和更准确的病理分期相关。方法：从荷兰上消化道癌症审计中回顾2011年至2016年期间接受胃切除术的患者。结果：共纳入2047例患者。在倾向评分匹配后，522例≥15个LNs的患者与522例患者进行了匹配。结论：在胃癌切除术中取出≥15个LNs与更高的pn分期相关，可能是分期迁移的结果。≥15个LNs患者的3年总生存率与2个LNs患者相当

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Surgery 医学-外科

CiteScore

4.90

自引率

3.70%

发文量

审稿时长

3 months

期刊介绍： ''Digestive Surgery'' presents a comprehensive overview in the field of gastrointestinal surgery. Interdisciplinary in scope, the journal keeps the specialist aware of advances in all fields that contribute to improvements in the diagnosis and treatment of gastrointestinal disease. Particular emphasis is given to articles that evaluate not only recent clinical developments, especially clinical trials and technical innovations such as new endoscopic and laparoscopic procedures, but also relevant translational research. Each contribution is carefully aligned with the need of the digestive surgeon. Thus, the journal is an important component of the continuing medical education of surgeons who want their practice to benefit from a familiarity with new knowledge in all its dimensions.