Continuous versus intermittent tube feeding after feeding jejunostomy, a pilot randomized controlled trial

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-05-17 DOI:10.1016/j.clnesp.2025.05.018

Peticha Tanprasert , Phanuwat Tharathipphayakun , Wasana Ko-iam , Sirikan Limpakan , Bandhuphat Chakrabandhu

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引用次数: 0

Abstract

Background

Feeding jejunostomy is employed in cases of upper gastrointestinal tract disorders; nonetheless, there are limited guidelines about post-procedural feeding approaches. This study aims to examine the effects of continuous and intermittent feeding strategies on time to achieve full feeding, gastrointestinal adverse events, and metabolic alterations following jejunostomy surgery.

Method

This randomized controlled pilot non-inferiority trial included 40 people with diseases of the upper GI tract who had a feeding jejunostomy at Chiang Mai University Hospital. The patients were not blinded and were randomly split into two groups using the block-of-four method. After completion of recruitment, 18 patients in the continuous feeding group and 20 patients in the intermittent feeding group (5 separated meals in 15 min each) were included in the final analysis. The primary outcome was determined based on the time to achieve complete feeding (30 ml/kg/day). The secondary outcome includes the presence of adverse gastrointestinal symptoms and any metabolic alterations.

Results

There were no statistically significant differences in the time taken to achieve a full feed in continuous and intermittent (48 ± 0 h. vs. 50.4 ± 5.6 h, p = 0.080) or as regards gastrointestinal adverse events, abdominal discomfort (27.8 vs. 30.0 %) and diarrhea (5.6 vs. 10 %) (p = 1.000). The metabolic outcome also showed no difference between the two groups.

Conclusion

There was no significant difference between continuous and intermittent feeding in terms of the time required to achieve a full feed, gastrointestinal adverse events such as abdominal discomfort and diarrhea, or metabolic changes.

Trial registration

TCTR20241008004; Thai Clinical Trials Registry.

查看原文本刊更多论文

饲喂空肠造口术后持续与间歇管喂养，一项随机对照试验。

背景：在上消化道疾病的病例中采用喂养式空肠造口术；尽管如此，关于术后喂养方法的指导方针有限。本研究旨在研究连续和间歇喂养策略对空肠造口手术后实现完全喂养的时间、胃肠道不良事件和代谢改变的影响。方法：这项随机对照试验纳入了清迈大学医院40例上消化道疾病患者进行喂养式空肠造口术。患者未采用盲法，采用四组法随机分为两组。招募完成后，连续喂养组18例患者和间歇喂养组20例患者（5次分餐，每次15分钟）纳入最终分析。主要结局根据实现完全喂养的时间（30 ml/kg/天）确定。次要结局包括不良胃肠道症状和任何代谢改变的存在。结果：连续饲喂和间歇饲喂（48±0小时）达到完全饲喂所需时间无统计学差异。Vs. 50.4±5.6小时。（p = 0.080）或胃肠道不良事件，腹部不适（27.8%对30.0%）和腹泻（5.6对10%）（p = 1.000）。代谢结果在两组之间也没有差异。结论：在达到饱食所需的时间、腹部不适和腹泻等胃肠道不良事件、代谢变化等方面，连续饲喂与间歇饲喂无显著差异。试验注册：TCTR20241008004；泰国临床试验登记处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.