Pathological perspective reveals a novel hemodialyzer reaction: a case report.

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY

BMC Nephrology Pub Date : 2025-05-19 DOI:10.1186/s12882-025-04180-6

Weijuan Lou, Yongchun Xi, Ya Liu, Xueling Cai, Junfang Gai, Jianyong Yin, Jiahui Ding, Yifang Yang, Yanjuan Teng, Tingfang Chen, Niansong Wang, Yongping Guo

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引用次数: 0

Abstract

Background: While the appearance of red clots in the dialyzer and the arterial and venous blood tubing lines is a common phenomenon in every hemodialysis unit, the occurrence of recurrent yellowish-white matter formation in the hemodialysis venous blood pot of a patient is rare.

Case presentation: We describe a male 69-year-old male with recurrent yellowish-white matter formation in the hemodialysis venous blood pot and red clots in the dialyzer. This was associated with a significant decrease in his red blood cells count. He had no history of thrombus no pro-thrombotic risk factors could be identified. Light microscopic examination of the deposits revealed the presence of large aggregates of neutrophils, large amounts of fibrin. The yellowish-white matter recurred at the next dialysis session. The occurrence of this episode was completely resolved by switching the dialysis filter and could not be avoided by increasing low molecular weight heparin dosage.

Conclusion: The yellowish-white matter and clotting within the dialyzer, as well as severe anemia, could be prevented by changing the type of dialyzer. Due to the rarity of this dialyzer reaction, it is important that awareness of this reaction by early identification be undertaken.

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病理角度揭示一种新的血液透析反应：1例报告。

背景：血透器及动、静脉血管中出现红色血块是每个血液透析单位的常见现象，但患者血液透析静脉血罐中反复出现黄白色物质形成是罕见的。病例介绍：我们报告一名69岁男性，血液透析静脉血罐中反复出现黄白色物质形成，并在透析器中出现红色凝块。这与他的红细胞计数显著减少有关。他没有血栓病史，也没有血栓形成的危险因素。光镜下检查发现大量中性粒细胞聚集，大量纤维蛋白。在下一次透析时，黄白色物质再次出现。该事件的发生可通过更换透析滤器完全解决，并不能通过增加低分子肝素剂量来避免。结论：通过改变透析器的类型，可以预防透析器内的黄白色物质和凝血，以及严重的贫血。由于这种透析器反应的罕见性，重要的是要通过早期识别来认识这种反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.