Strategies for the optimisation of troublesome peptide nucleic acid (PNA) sequences.

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-20 DOI:10.1039/d5ob00589b

Emma E Watson

引用次数: 0

Abstract

Through the use of a pseudo-peptidic backbone, peptide nucleic acids (PNA) mimic the functionality of native nucleic acids while enjoying improved binding affinity and metabolic stability. However, many aspects of the application of PNA to biological and medicinal settings still requires sequence specific optimisation. This review highlights key areas for refinement, including synthesis, tuning of physical properties, cell permeability and analysis, including common strategies for the pracitioner to apply in each area.

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棘手的肽核酸（PNA）序列优化策略。

通过使用伪肽骨架，肽核酸（PNA）模仿天然核酸的功能，同时具有更好的结合亲和力和代谢稳定性。然而，PNA应用于生物学和医学设置的许多方面仍然需要特定的序列优化。这篇综述强调了改进的关键领域，包括合成，物理性质的调整，细胞渗透性和分析，包括从业者在每个领域应用的共同策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.