A Stable and Local H2 Nanogenerator for Antifading Responses.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2025-06-16 Epub Date: 2025-05-19 DOI:10.1021/acsabm.5c00533
Jiaying Cao, Mingwei Zhong, Siyu Wang, Qibin Li, Wei Ma, Xiaodong Yan, Jing Wang, Yuan Zhao
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引用次数: 0

Abstract

Persistent inflammation effects existed in the senescence microenvironment, and hydrogen (H2) was an antioxidant stress agent and could solve the aging and inflammation. In view of the issue of low solubility of H2 and conversion efficiency of traditional hydrogen therapy, an in-site hydrogen production system (HPS) was designed by using liposome as a compartment, emodin as a photosensitizer, l-ascorbic acid-2-phosphate trisodium salt (AAP) as hydrogen sources, and Au NPs as photocatalysts. Different from the commonly used chlorophyll A, emodin with strong absorption in the wide range of 200-500 nm could absorb more photons to form electrons for the participation of H2 generation. Emodin- and AAP-embedded HPS largely increased stability at 50 °C for 28 days. HPS facilitated the decrease of inflammatory factors of TNF-α, IL-6, and ROS in RAW264.7 cells, as well as the elimination of senescence-associated β-galactosidase, realizing convenient and efficient antifading responses. But strikingly, the constructed HPS can penetrate the pig skin in transdermal experiments and showed huge prospects for the application of antifading cosmetics.

抗衰落响应的稳定局部H2纳米发生器。
衰老微环境中存在持续的炎症效应,而氢(H2)是一种抗氧化应激剂,可以解决衰老和炎症。针对H2溶解度低和传统氢疗法转化效率低的问题,以脂质体为隔室,大黄素为光敏剂,l-抗坏血酸-2-磷酸三钠盐(AAP)为氢源,Au NPs为光催化剂,设计了一种现场制氢系统(HPS)。与常用的叶绿素A不同,大黄素在200-500 nm的宽范围内吸收能力强,可以吸收更多的光子形成电子参与H2的生成。大黄素和aap包埋的HPS在50°C下28天的稳定性大大提高。HPS可降低RAW264.7细胞中炎症因子TNF-α、IL-6、ROS,消除衰老相关β-半乳糖苷酶,实现便捷高效的抗衰老反应。但令人惊讶的是,构建的HPS在透皮实验中可以穿透猪皮肤,在抗褪色化妆品中具有巨大的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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