History of Previous Medication Self-Discontinuation Predicts the Current Adherence to 5-Aminosalicylates in Patients With Ulcerative Colitis

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-05-20 DOI:10.1002/jgh3.70181

Shogo Kitahata, Ayaka Nakamura, Yuka Kimura, Mai Fukumoto, Kana Matsuoka, Takuya Matsuda, Kazuya Murakawa, Taisei Murakami, Kei Onishi, Hirofumi Izumoto, Kozue Kanemitsu-Okada, Tomoe Kawamura, Taira Kuroda, Junko Matsuoka, Fujimasa Tada, Hideki Miyata, Atsushi Hiraoka, Kazuhiro Tange, Yasunori Yamamoto, Eiji Takeshita, Yoshiou Ikeda, Shinya Furukawa, Eiji Tsubouchi, Tomoyuki Ninomiya, Yoichi Hiasa

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Abstract

Aim

Medication adherence is critical in 5-aminosalicylate therapy for patients with ulcerative colitis. Patients with a history of previous medication self-discontinuation may continue to have low adherence due to the influence of inappropriate disease awareness. This study aimed to determine the association between the history of previous medication self-discontinuation and current adherence to 5-aminosalicylates in patients with ulcerative colitis.

Methods and Results

This cross-sectional study was conducted in Japan from 2021 to 2024. A self-administered questionnaire was used in 228 patients with ulcerative colitis who were taking 5-aminosalicylates. We defined adherence as consumption of ≥ 80% of the prescribed dose. Patients with a history of previous medication self-discontinuation were defined as having discontinued medication at least once in the past by their own judgment. The current adherence rate to 5-aminosalicylates in this study was 92.9% (212/228). The proportion of patients with a history of previous medication self-discontinuation was 7.8% (18/228). History of previous medication self-discontinuation (p < 0.001), younger age (p < 0.001), and once-daily 5-aminosalicylates regimen (p < 0.001) were inversely associated with current adherence to 5-aminosalicylates.

Conclusion

History of previous medication self-discontinuation was inversely associated with current adherence to 5-aminosalicylates among patients with ulcerative colitis. The results of this study suggest that determining the history of previous medication self-discontinuation may be a valuable tool in assessing current adherence to 5-aminosalicylates, which can be cumbersome.

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既往自我停药史预测溃疡性结肠炎患者目前对5-氨基水杨酸盐的依从性

目的：在溃疡性结肠炎患者的5-氨基水杨酸治疗中，药物依从性至关重要。既往有自我停药史的患者，由于疾病意识不恰当的影响，依从性可能仍然较低。本研究旨在确定溃疡性结肠炎患者既往自我停药史与当前5-氨基水杨酸盐依从性之间的关系。方法与结果本横断面研究于2021 - 2024年在日本进行。对228例服用5-氨基水杨酸盐的溃疡性结肠炎患者进行问卷调查。我们将依从性定义为服用处方剂量的≥80%。既往有自我停药史的患者定义为过去自行判断至少停药一次。在本研究中，目前5-氨基水杨酸盐的依从率为92.9%（212/228）。有自我停药史的患者比例为7.8%（18/228）。既往自我停药史（p < 0.001）、年龄较小（p < 0.001）和每日一次的5-氨基水杨酸盐方案（p < 0.001）与目前坚持使用5-氨基水杨酸盐呈负相关。结论溃疡性结肠炎患者既往自我停药史与当前5-氨基水杨酸盐依从性呈负相关。本研究的结果表明，确定先前药物自我停药的历史可能是评估当前5-氨基水杨酸盐依从性的一个有价值的工具，这可能是麻烦的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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