Protective Impacts of Quercetin and Echinochrome on Female Fertility and Pregnancy Outcomes in Polycystic Ovary Syndrome in Rats

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2025-05-21 DOI:10.1002/bdr2.2487

Rokia Gamal Mohamed, Ayman Saber Mohamed, Ahmed Imam Dakrory, Mennatallah H. Abdelaziz

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引用次数: 0

Abstract

Background

Polycystic ovary syndrome (PCOS) is a universal reproductive, endocrine, and metabolic disorder. It affects 9.2% of women worldwide. Echinochrome (Ech) is the most common dark red pigment of sea urchin shells and possesses high antioxidant and hypoglycemic properties. Quercetin (Quer) is a flavonol widely distributed in plants with high antioxidant properties. Therefore, Ech and Quer as a combined protective therapy were investigated against letrozole and high-fat diet-induced PCOS model in rats.

Methods

Sixty female rats were divided randomly into five groups: Control: received 2% DMSO with a normal diet, PCOS: received letrozole with HFD, Ech: received letrozole and Ech with HFD, Quer: received letrozole and Quer with HFD, Ech + Quer: received letrozole, Ech, and Quer together daily orally for 4 weeks. Half of the rats in each group were sacrificed, and the remaining rats were examined for their ability to mate and fertility.

Results

Ech and Quer treatment restored normal levels of lipid and hormonal profiles, oxidative status, kidney and liver functions with a marked amelioration in ovarian, uterine histopathology, and a good evidence in pregnancy analysis.

Conclusion

Ech and Quer were found to have a potent protective effect against PCOS, minimal side effects, and improved progeny outcomes in rats.

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槲皮素和紫皮色素对多囊卵巢综合征大鼠雌性生殖能力和妊娠结局的保护作用

多囊卵巢综合征（PCOS）是一种普遍的生殖、内分泌和代谢疾病。它影响了全球9.2%的女性。海胆色素（Ech）是海胆壳中最常见的暗红色色素，具有较高的抗氧化和降糖性能。槲皮素是一种广泛存在于植物中的黄酮醇，具有较高的抗氧化性。因此，我们研究了Ech和Quer作为联合保护疗法对来曲唑和高脂饮食诱导的PCOS大鼠模型的保护作用。方法雌性大鼠60只，随机分为5组：对照组：正常饮食给予2%二甲二甲基二甲磺酸；PCOS组：来曲唑合并HFD组；Ech组：来曲唑+ Ech组：来曲唑+ Quer组：来曲唑+ Quer组：来曲唑+ Ech + Quer组：来曲唑+ Ech + Quer组：来曲唑+ Ech + Quer组：来曲唑+ Ech + Quer组：来曲唑+ Ech + Quer组，每日口服4周。每组一半的大鼠被处死，剩下的大鼠被检查它们的交配能力和生育能力。结果Ech和Quer治疗后，小鼠脂质、激素、氧化状态、肾功能和肝功能恢复正常，卵巢、子宫组织病理学有明显改善，妊娠分析有良好证据。结论Ech和Quer对PCOS有较强的保护作用，副作用小，可改善大鼠后代结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.