In vitro inhibitory effect of selected drugs on mycelial growth of the fungus Pleurotus ostreatus and Pleurotus djamor

Abstract

Emerging contaminants are characterized by being substances that have gained importance in recent years due to their high consumption by both humans and animals, mainly drugs, which base their importance on being present in both drinking water bodies and wastewater as they are not completely assimilated by the body. In the present work, fifteen different media prepared with white potato without dextrose (PBA), white potato with dextrose (PBDA), potato and carrot (PZA), and eleven different cereals: wheat flour (HTA), corn flour (HMA), pumpkin flour (HCA), yellow bean flour (HFAA), black bean flour (HFNA), purple bean flour (HFMA), broad bean flour (HHA), oat flour (HAA), rice flour (HAZA), chickpea flour (HGA) and commercial wheat flour (HTCA) were evaluated to carry out the growth of two basidiomycete fungi P. ostreatus and P. djamor. Additionally, the adaptation capacity of these fungi to seven concentrations (1, 3, 5, 10, 20, 25 and 50 mg∙L⁻¹) of five drugs (diclofenac, paracetamol, carbamazepine, ciprofloxacin and ampicillin) was determined. For this purpose, their radial growth and morphological characteristics were monitored daily. The results showed good growth for both fungi in media prepared with wheat flour and purple beans; and a tolerance capacity to the contaminants evaluated of up to 5 mg∙L⁻¹.