Subclinical ventricular dysfunction in rheumatoid arthritis

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Ameni Mardessi, Houaida Mahfoudhi, Sarra Chenik, Taha Yassine Jabloun, Abdedayem Haggui, Nadhem Hajlaoui, Wafa Fehri
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引用次数: 0

Abstract

Introduction

Cardiovascular disease, especially heart failure, is often under diagnosed in patients with rheumatoid arthritis (RA). Heart failure in RA patients presents with distinctives features, such as preserved ejection fraction and higher mortality rates compared to the non-RA population. Despite its accessibility and safety, echocardiography has not been widely recommended for screening in this patient population.

Objective

In our study, we aimed to assess the utility of speckle tracking echocardiography in detecting sub clinical ventricular dysfunction

Method

We conducted a prospective study that included 36 patients with RA who were being treated at the rheumatology department of the military hospital in Tunis. Weal so enrolled 36 control cases who had undergone echocardiography at the cardiology department of the same hospital, selected based on age, sex, and BMI to match the first group.

Results

The mean age of the participants was 51.69 ± 12.14 years, with a predominance of females, resulting in a sex ratio of 0.33. The mean Body mass index (BMI) was28.17 ± 4.27 kg/m2. Diabetes mellitus (DM) was the most common comorbidity, occurring in 9 patients (25%). There were no statistically significant differences between the RA and control groups in terms of matching parameters (age, sex, and BMI). No statistically significant differences were observed between the two groups in terms of left ventricular measurements and systolic function, all of which fell within normal ranges, with a median left ventricular ejection fraction (LVEF) of71%. However, the study of diastolic function revealed that 19% of RA patients and 14% of control subjects had grade I diastolic dysfunction, all of whom were over 50 years of age, and none exhibited high filling pressures. When comparing Global Longitudinal Strain (GLS) measurements between the two groups, it was evident that RA patients had significantly lower GLS (P = 0.015) than the control group, and sub clinical left ventricular systolic dysfunction was observed exclusively in RA patients. Age and diabetes mellitus were both found to be correlated with GLS in RA patients. Age at the time of RA diagnosis exhibited a weak correlation with GLS (r = −0.305, P = 0.07).

Conclusion

Rheumatoid arthritis emerges as a risk factor for cardiovascular disease. The study of myocardial deformation offers a valuable method for screening sub clinical myocardial lesions and facilitating early therapeutic intervention.
类风湿关节炎的亚临床心室功能障碍
类风湿性关节炎(RA)患者常被误诊为心血管疾病,尤其是心力衰竭。与非RA人群相比,RA患者的心力衰竭表现出独特的特征,如保留射血分数和更高的死亡率。尽管超声心动图具有可及性和安全性,但尚未广泛推荐用于该患者人群的筛查。在我们的研究中,我们旨在评估斑点跟踪超声心动图在检测亚临床心室功能障碍中的应用。方法我们进行了一项前瞻性研究,包括36名在突尼斯军队医院风湿病科治疗的RA患者。wealso招募了36例对照病例,他们在同一家医院的心脏病科接受了超声心动图检查,根据年龄、性别和BMI进行选择,与第一组相匹配。结果调查对象平均年龄为51.69±12.14岁,女性居多,性别比为0.33。平均体重指数(BMI)为28.17±4.27 kg/m2。糖尿病(DM)是最常见的合并症,共发生9例(25%)。RA组和对照组在匹配参数(年龄、性别和BMI)方面没有统计学上的显著差异。两组左心室测量和收缩功能无统计学差异,均在正常范围内,中位左心室射血分数(LVEF)为71%。然而,舒张功能的研究显示,19%的RA患者和14%的对照组存在I级舒张功能障碍,所有患者年龄均在50岁以上,没有人表现出高充盈压力。比较两组患者的GLS (Global Longitudinal Strain)测量结果,RA患者GLS明显低于对照组(P = 0.015),且仅在RA患者中观察到亚临床左室收缩功能障碍。年龄和糖尿病均与RA患者GLS相关。RA诊断时的年龄与GLS呈弱相关(r = - 0.305, P = 0.07)。结论类风湿关节炎是心血管疾病的危险因素。心肌变形的研究为筛选亚临床心肌病变,促进早期治疗干预提供了有价值的方法。
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来源期刊
Archives of Cardiovascular Diseases
Archives of Cardiovascular Diseases 医学-心血管系统
CiteScore
4.40
自引率
6.70%
发文量
87
审稿时长
34 days
期刊介绍: The Journal publishes original peer-reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches, review articles and editorials. Topics covered include coronary artery and valve diseases, interventional and pediatric cardiology, cardiovascular surgery, cardiomyopathy and heart failure, arrhythmias and stimulation, cardiovascular imaging, vascular medicine and hypertension, epidemiology and risk factors, and large multicenter studies. Archives of Cardiovascular Diseases also publishes abstracts of papers presented at the annual sessions of the Journées Européennes de la Société Française de Cardiologie and the guidelines edited by the French Society of Cardiology.
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