Operating characteristics of nebulizers used for intraperitoneal aerosolized drug delivery

IF 2.9 3区环境科学与生态学 Q2 ENGINEERING, CHEMICAL

Journal of Aerosol Science Pub Date : 2025-05-18 DOI:10.1016/j.jaerosci.2025.106615

Mohammad Rahimi-Gorji , Lotte Desmet , Stéphane Dorbolo , Charlotte Debbaut , Sarah Cosyns , Wouter Willaert , Wim Ceelen

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引用次数: 0

Abstract

Intraperitoneal aerosolized drug delivery (IPADD) is a minimally invasive technique for treating peritoneal metastasis (PM), combining laparoscopy with locoregional chemotherapy delivery as an aerosol. This study investigated key operating and physical parameters affecting IPADD performance, focusing on aerosolization pressure, droplet size distribution (DSD), and spray cone angle using six commercialized nebulizers: Nebulizer 770-12 (REGER Medizintechnik), CapnoPen™(CapnoPharm), HurriChem™ (ThermaSolutions), MCR-4 TOPOL™ (Skala), QuattroJet™ (REGER Medizintechnik), and MiniJet (REGER Medizintechnik) in a reconstructed peritoneal cavity model. Results indicated notable variations in nebulizer performance. Nebulizer 770-12, CapnoPen, and HurriChem showed similar technical characteristics and reliable performance. DSD analysis showed bimodal distributions, with MiniJet and HurriChem producing small droplets (10–20 μm), while MCR-4 TOPOL generated larger droplets due to its larger orifice and distinctive design. Spray cone angle measurements demonstrated that higher flow rates slightly improved dispersion, with the MCR-4 TOPOL achieving the widest angles. Optimal flow rates for uniform spray patterns varied, with CapnoPen and HurriChem performing well at lower rates, while MCR-4 TOPOL and QuattroJet required higher flow rates (>1.0 mL/s). This comprehensive evaluation provides valuable insights to optimize nebulizer selection and aerosolized drug delivery for improved IPADD efficacy.

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腹腔雾化给药用雾化器的工作特性

腹腔雾化给药（IPADD）是一种治疗腹膜转移（PM）的微创技术，将腹腔镜与局部化疗雾化给药相结合。本研究研究了影响IPADD性能的关键操作和物理参数，重点关注雾化压力、液滴大小分布（DSD）和喷雾锥角，使用六种商业化雾化器：雾化器700 -12 （REGER Medizintechnik）、CapnoPen™（CapnoPharm）、HurriChem™（ThermaSolutions）、MCR-4 TOPOL™（Skala）、QuattroJet™（REGER Medizintechnik）和MiniJet （REGER Medizintechnik）在重建腹腔模型中。结果表明，雾化器的性能有显著的变化。雾化器770-12、CapnoPen和飓风显示出相似的技术特征和可靠的性能。DSD分析显示出双峰分布，MiniJet和hurricane产生的液滴较小（10-20 μm），而MCR-4 TOPOL由于其较大的孔口和独特的设计而产生较大的液滴。喷淋锥角测量表明，更高的流量略微改善了分散性，MCR-4 TOPOL达到了最宽的角度。均匀喷雾模式的最佳流速各不相同，CapnoPen和hurricane在较低的流速下表现良好，而MCR-4 TOPOL和QuattroJet需要更高的流速（1.0 mL/s）。这一综合评价为优化雾化器选择和雾化给药提供了有价值的见解，以提高IPADD的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Aerosol Science 环境科学-工程：化工

CiteScore

8.80

自引率

8.90%

发文量

127

审稿时长

35 days

期刊介绍： Founded in 1970, the Journal of Aerosol Science considers itself the prime vehicle for the publication of original work as well as reviews related to fundamental and applied aerosol research, as well as aerosol instrumentation. Its content is directed at scientists working in engineering disciplines, as well as physics, chemistry, and environmental sciences. The editors welcome submissions of papers describing recent experimental, numerical, and theoretical research related to the following topics: 1. Fundamental Aerosol Science. 2. Applied Aerosol Science. 3. Instrumentation & Measurement Methods.