Neuromagnetic responses to multimodal stimuli in Friedreich’s ataxia

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-05-13 DOI:10.1016/j.clinph.2025.2110738

Elisa Visani , Laura Canafoglia , Lorenzo Nanetti , Davide Rossi Sebastiano , Dunja Duran , Paola Anversa , Deborah Bonfoco , Sara Dotta , Davide Tabarelli , Anna Castaldo , Gloria Marchini , Alessia Mongelli , Caterina Mariotti

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引用次数: 0

Abstract

Objective

This study explores the utility of various evoked fields in elucidating the pathophysiology of Friedreich’s ataxia (FA) and potentially contributing to developing more targeted diagnostic and therapeutic strategies.

Methods

Thirty-seven patients with FA aged 27.6 ± 7.4 years and a control group of 17 healthy subjects were enrolled in the study. The neuromagnetic response to auditory, tactile, visual, somatosensory, auditory and tactile oddball stimulation were acquired. For all the components of interest, latency and amplitude were measured and correlated with clinical data.

Results

Neuromagnetic responses were identifiable in more than 90% of cases. A significant response delay was observed in all tested modalities (auditory, somatosensory, tactile and visual responses). P300 responses were comparable in patients and healthy subjects. Latencies of visual and auditory responses correlated with SARA scores. Moreover, latencies of auditory responses correlated with disease onset age, whereas latencies of visual responses correlated with disease severity.

Conclusions

Auditory and visual responses correlated with the severity of the disease, whereas alterations in somatosensory responses represent an intrinsic characteristic of the disease.

Significance

In FA the study of evoked visual fields could provide a possible biomarker of disease progression and treatment efficacy.

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弗里德赖希共济失调对多模态刺激的神经磁反应

目的探讨各种诱发场在阐明弗里德赖希共济失调（FA）病理生理学中的作用，为制定更有针对性的诊断和治疗策略提供潜在的帮助。方法选取年龄（27.6±7.4）岁的FA患者37例和健康对照组17例。获得了听觉、触觉、视觉、体感、听觉和触觉奇球刺激的神经磁反应。对于所有感兴趣的成分，潜伏期和振幅被测量并与临床数据相关联。结果90%以上的病例可识别神经磁反应。在所有测试模式（听觉、体感、触觉和视觉反应）中都观察到显著的反应延迟。P300反应在患者和健康受试者中具有可比性。视觉和听觉反应潜伏期与SARA评分相关。此外，听觉反应潜伏期与疾病发病年龄相关，而视觉反应潜伏期与疾病严重程度相关。结论：听觉和视觉反应与疾病的严重程度相关，而体感反应的改变代表了疾病的内在特征。意义在FA中，诱发视野的研究可为疾病进展和治疗效果提供可能的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.