Regenerable liquid metal nanozymes enable pH-regulated multi-enzyme mimicking

IF 17.3 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Matter Pub Date : 2025-06-04 DOI:10.1016/j.matt.2025.102159

Yuhe Shen , Ruizhe Xing , Xiaojian Xu , Yuefei Wang , Renliang Huang , Rongxin Su , Michael D. Dickey , Wei Qi , Jie Kong

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Abstract

Nanozymes are nanomaterials with enzyme-like characteristics that are found in the fields of catalysis, biomedicine, and environmental science. In this work, we present a core-shell liquid metal nanozyme (MnO_x@EGaIn) that shows pH-regulated multi-enzyme mimicking capabilities. By harnessing the amphoteric nature of liquid metal surface oxides, these liquid metal nanozymes demonstrate tunable reaction possibilities under various pH conditions (4.0–9.5). This property enables highly efficient enzyme-mimicking activities, including oxidase (OXD, specific activity, SA of 539 U/g), catalase (CAT, SA of 2621 U/g), and superoxide dismutase (SOD, SA of 2391 U/g). Moreover, these liquid metal nanozymes showed notable regenerability, allowing them to be recycled and re-synthesized from their raw material forms. This discovery not only broadens the range of materials and applications for nanozymes but also equips them with the ability to perform multiple enzyme functions while remaining regenerative, providing valuable insights for the design of next-generation enzyme-mimicking materials.

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可再生液态金属纳米酶使ph调节的多酶模拟

纳米酶是一种具有酶样特性的纳米材料，在催化、生物医学和环境科学等领域都有应用。在这项工作中，我们提出了一种核壳液态金属纳米酶（MnOx@EGaIn），它显示了ph调节的多酶模拟能力。通过利用液态金属表面氧化物的两性性质，这些液态金属纳米酶在各种pH条件下（4.0-9.5）表现出可调的反应可能性。这种特性使其具有高效的酶模拟活性，包括氧化酶（OXD，比活性，SA为539 U/g），过氧化氢酶（CAT， SA为2621 U/g）和超氧化物歧化酶（SOD， SA为2391 U/g）。此外，这些液态金属纳米酶表现出显著的可再生性，使它们能够从其原料形式中回收和重新合成。这一发现不仅拓宽了纳米酶的材料和应用范围，而且使它们具有在保持再生的同时执行多种酶功能的能力，为设计下一代酶模拟材料提供了有价值的见解。

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来源期刊

Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

26.30

自引率

2.60%

发文量

367

期刊介绍： Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.