ETS emerges to heat up adipose

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-05-19 DOI:10.1101/gad.352966.125

Matthew S. Rodeheffer

引用次数: 0

Abstract

In this issue of Genes & Development, Xue and colleagues (doi:10.1101/gad.352748.125) identify ETV4 as a transcription factor binding a −12 kb enhancer of UCP1 to promote chromatin accessibility, histone acetylation, and gene expression. This role for ETV4 in thermogenesis expands its known functions in adipogenesis. Importantly, these findings also highlight an emerging, broader role for E26 transformation-specific (ETS) transcription factors in adipose biology.

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ETS的出现是为了加热脂肪

在本期的《基因》杂志上；Development， Xue及其同事（doi:10.1101/gad.352748.125）发现ETV4是一种结合UCP1 - 12 kb增强子的转录因子，可促进染色质可及性、组蛋白乙酰化和基因表达。ETV4在产热中的作用扩展了其在脂肪形成中的已知功能。重要的是，这些发现还强调了E26转化特异性（ETS）转录因子在脂肪生物学中的新兴、更广泛的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).