{"title":"Prilocaine-Induced Methemoglobinemia During Surgically Assisted Rapid Palatal Expansion (SARPE) Under General Anesthesia: A Case Report.","authors":"Yusuke Kurosawa, Karen Gomi, Akinori Moroi, Kunio Yoshizawa, Koichiro Ueki","doi":"10.1155/crid/9917154","DOIUrl":null,"url":null,"abstract":"<p><p>Methemoglobinemia is a condition in which methemoglobin levels in the blood increase. Methemoglobin lacks oxygen-binding ability, resulting in oxygen deprivation in tissues. This high level of methemoglobin in the blood presents as a severely worsening condition. Herein, we report a case of methemoglobinemia caused by the administration of 3% prilocaine hydrochloride containing 0.03 IU/mL feripressin as a local anesthetic during orthognathic surgery. Following drug administration, the patient's atrial oxygen saturation (SpO<sub>2</sub>) decreased. We diagnosed methemoglobinemia based on arterial blood gas analysis, which revealed an increased level of methemoglobin. To maintain the SpO<sub>2</sub> level, oxygen was administered. The patient's condition improved over time. Careful monitoring and maintenance of SpO<sub>2</sub> levels are essential to ensure proper diagnosis and effective management.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2025 ","pages":"9917154"},"PeriodicalIF":0.7000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084793/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/crid/9917154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Methemoglobinemia is a condition in which methemoglobin levels in the blood increase. Methemoglobin lacks oxygen-binding ability, resulting in oxygen deprivation in tissues. This high level of methemoglobin in the blood presents as a severely worsening condition. Herein, we report a case of methemoglobinemia caused by the administration of 3% prilocaine hydrochloride containing 0.03 IU/mL feripressin as a local anesthetic during orthognathic surgery. Following drug administration, the patient's atrial oxygen saturation (SpO2) decreased. We diagnosed methemoglobinemia based on arterial blood gas analysis, which revealed an increased level of methemoglobin. To maintain the SpO2 level, oxygen was administered. The patient's condition improved over time. Careful monitoring and maintenance of SpO2 levels are essential to ensure proper diagnosis and effective management.
期刊介绍：
Case Reports in Dentistry is a peer-reviewed, Open Access journal that publishes case reports and case series in all areas of dentistry, including periodontal diseases, dental implants, oral pathology, as well as oral and maxillofacial surgery.
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