Recent advances in the application of nanotechnology in joint arthroplasty: a narrative review.

IF 0.5 4区 医学 Q4 ORTHOPEDICS
Annals of Joint Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI:10.21037/aoj-24-50
Whisper Grayson, Nicholas M Brown
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引用次数: 0

Abstract

Background and objective: Osteoarthritis (OA) is a multifactorial disease, involving biomechanical, inflammatory, and metabolic processes that ultimately impact the structure and function of a joint. Current therapeutic options can improve symptoms and prolong the time to surgery, yet they are not curative and are limited by their systemic side-effects and their inability to provide site-specific delivery. Nanomedicine takes advantage of the unique properties held by technology on the nanoscale (1-100 nm), including surface effects and quantum effects, that allow for novel mechanical, thermal, and magnetic functions. The primary aim of this narrative review is to summarize the recent advances made in nanotechnology and their uses in joint arthroplasty.

Methods: This narrative review was performed following a computerized search of the electronic database on PubMed in September 2024. Papers related to the use of nanotechnology in orthopaedic arthroplasty surgery were included for review.

Key context and findings: Nanotechnology holds the promise of optimizing OA treatment, refining the implants used during joint arthroplasty, and aiding in the diagnosis and treatment of post-operative joint infections. With the increasingly aging population and growing demand for joint replacement, this review aims to cover the novel applications of nanoparticles (NPs) within the realm of joint replacement surgery.

Conclusions: Future studies are needed to further investigate the clinical translation of NPs in joint arthroplasty. Additionally, the potential of NPs needs to be considered within their limitations and their safety profile that is still being defined.

纳米技术在关节成形术中的应用进展:综述。
背景和目的:骨关节炎(OA)是一种多因素疾病,涉及生物力学、炎症和代谢过程,最终影响关节的结构和功能。目前的治疗方案可以改善症状并延长手术时间,但它们不能治愈,并且受到全身副作用和无法提供部位特异性递送的限制。纳米医学利用了纳米(1-100纳米)技术所具有的独特特性,包括表面效应和量子效应,从而实现了新的机械、热和磁功能。这篇叙述性综述的主要目的是总结纳米技术的最新进展及其在关节成形术中的应用。方法:本叙述性综述是在2024年9月对PubMed电子数据库进行计算机检索后进行的。有关纳米技术在矫形关节成形术中的应用的论文被纳入综述。关键背景和发现:纳米技术有望优化骨关节炎治疗,改进关节成形术中使用的植入物,并有助于术后关节感染的诊断和治疗。随着人口老龄化和关节置换需求的增加,本文旨在介绍纳米颗粒(NPs)在关节置换手术领域的新应用。结论:NPs在关节成形术中的临床转化有待进一步研究。此外,需要在其局限性和仍在确定的安全性范围内考虑核反应堆的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Joint
Annals of Joint ORTHOPEDICS-
CiteScore
1.10
自引率
-25.00%
发文量
17
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