MRI-based pseudo-CT sequences as a radiation-free alternative to CT for obstetric pelvimetry: a proof-of-concept study.

Abstract

Background: Pelvimetry is essential in obstetrics for delivery planning. While computed tomography (CT) is the standard, magnetic resonance imaging (MRI) offers a radiation-free alternative with zero echo time (ZTE) and black bone (BB) sequences providing high bone-to-soft tissue contrast within short scan times. This proof-of-concept study evaluates the reliability of these sequences and the agreement with CT for pelvimetry in a predominantly elderly population.

Methods: This retrospective study included 21 female patients who underwent 3-T whole-body MRI including ZTE and BB sequences and ¹⁸fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/CT with optimized low-dose whole-body CT. Obstetric conjugate diameter (OCD), interspinous diameter (ISD), and median transverse diameter (MTD) were measured by five radiologists. Intra-reader, inter-reader, and inter-technique agreement were assessed using intraclass correlation coefficient (ICC) and repeatability/reproducibility coefficients.

Results: Intra-reader agreement was good regardless of diameter or reader: all ICC ≥ 0.90, repeatability ranging from ± 0.26 to ± 0.48 cm (CT), ± 0.30 to ± 0.52 cm (BB), and ± 0.29 to ± 0.67 cm (ZTE). The inter-reader agreement was good regardless of sequence: all ICC ≥ 0.88, reproducibility ranging from ± 0.39 to ± 0.42 (OCD), ± 0.26 to ± 0.51 cm (ISD), and ± 0.53 to ± 0.58 cm (MTD). ZTE and BB showed similar agreement with CT: ± 0.57 to ± 0.81 cm when including inter-reader variability; ± 0.34 to ± 0.47 cm for only intra-reader variability.

Conclusion: ZTE and BB sequences provided reliable measurements with good agreement with CT, for obstetric pelvimetry. Further validation in the context of pregnancy is needed.

Relevance statement: MRI-based pseudo-CT sequences are a promising radiation-free alternative to CT for obstetric pelvimetry, offering the prospect of accurate, reliable measurements of pelvic diameters in pregnant women.

Trial registration: The population included female patients with suspected multiple myeloma from a previous prospective oncology trial (ClinicalTrials.gov: NCT05381077).

Key points: This study explores pseudo-CT MRI sequences for radiation-free non-invasive obstetric pelvimetry. Pseudo-CT zero echo time and black bone sequences provide repeatable and reproducible measurements of pelvic diameters. Pseudo-CT MRI sequences show good inter-technique agreement with the reference CT.