[Relation of metabolic-associated fatty liver disease to the complications of diabetes mellitus].

Abstract

Fatty liver has become one of the most common chronic liver diseases worldwide. During its progression, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma may develop. Fatty liver disease of metabolic origin occurs in nearly 30% of adults, it affects people with diabetes mellitus to a greater extent. Its incidence is 70% in type 2 diabetes mellitus, and 30–40% in type 1 diabetes mellitus. The global health burden of fatty liver disease of metabolic origin means an increased risk not only of hepatic (e.g., cirrhosis, liver failure or hepatocellular carcinoma) but also of extrahepatic (e.g., cardiovascular, and neoplastic diseases) complications. Both type 1 and type 2 diabetic patients with fatty liver disease have a higher mortality rate. These patient groups are exposed to an increased risk not only of cardiovascular diseases, but also of diabetic retinopathy and nephropathy, compared to diabetics not associated with fatty liver disease. In our summary, we review how the coexistence of fatty liver and type 1 and type 2 diabetes mellitus affects the frequency of diabetic macro- and microvascular complications. Orv Hetil. 2025; 166(20): 759–767.