Relationship Between Cerebral Glucose Metabolism and Neurodevelopmental Outcomes in Very-Low-Birth-Weight Infants without Structural Abnormalities.

IF 2.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine and Molecular Imaging Pub Date : 2025-06-01 Epub Date: 2024-12-07 DOI:10.1007/s13139-024-00893-y

Jae Hyun Park, Jimin Yuei, Soyoung Lee, Jungsu S Oh, Kyoung Sook Won, Hae Won Kim

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引用次数: 0

Abstract

Purpose: Very-low-birth-weight (VLBW) infants are more likely to have poor neurodevelopmental outcomes, even if structural abnormalities are not observed during brain magnetic resonance imaging (MRI). The purpose of the present study was to determine whether cerebral glucose metabolism is correlated with neurodevelopmental outcomes in VLBW infants without structural abnormalities.

Methods: Twenty-seven VLBW infants (birth weight < 1,500 g) without structural abnormalities were prospectively enrolled. All infants underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) examinations at term-equivalent ages, and the regional glucose metabolic ratios were calculated. Neurodevelopmental outcomes were assessed using the Mental Development Index (MDI) and the Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development-II at a corrected age of 18-24 months. Poor neurodevelopmental outcomes were defined as an MDI or PDI score < 85.

Results: The glucose metabolic ratio in the right central region of the brain was significantly correlated with the MDI score (r = 0.505, p = 0.007). The glucose metabolic ratios in the right central region and right insula in the poor-neurodevelopmental-outcome group were significantly lower than those in the good-neurodevelopmental-outcome group (1.03 ± 0.02 vs. 1.08 ± 0.04, p = 0.004, and 1.08 ± 0.05 vs. 1.13 ± 0.05, p = 0.018, respectively). Furthermore, the right central region and insula exhibited large extent of metabolic connectivity in infants with good neurodevelopmental outcome than that in infants with poor neurodevelopmental outcome.

Conclusions: Cerebral glucose metabolism was correlated with the neurodevelopmental outcomes of VLBW infants at a corrected age of 18-24 months.

Supplementary information: The online version contains supplementary material available at 10.1007/s13139-024-00893-y.

查看原文本刊更多论文

无结构异常的极低出生体重儿脑糖代谢与神经发育结局的关系

目的：极低出生体重（VLBW）婴儿更可能有不良的神经发育结果，即使在脑磁共振成像（MRI）中没有观察到结构异常。本研究的目的是确定脑糖代谢是否与无结构异常的VLBW婴儿的神经发育结局相关。结果：右脑中央区糖代谢率与MDI评分有显著相关性（r = 0.505, p = 0.007）。神经发育不良组右中央区和右岛糖代谢率显著低于神经发育良好组（分别为1.03±0.02比1.08±0.04,p = 0.004, 1.08±0.05比1.13±0.05,p = 0.018）。此外，与神经发育不良的婴儿相比，神经发育良好的婴儿的右侧中央区域和脑岛表现出更大程度的代谢连通性。结论：脑糖代谢与18-24月龄VLBW婴儿的神经发育结局相关。补充信息：在线版本包含补充资料，提供地址：10.1007/s13139-024-00893-y。

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来源期刊

Nuclear Medicine and Molecular Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.20

自引率

7.70%

发文量

期刊介绍： Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor. The Korean Society of Nuclear Medicine (KSNM) KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.