Inverted L-shape association between a body shape index and peak expiratory flow among middle-aged and older adults: findings from the China Health and Retirement Longitudinal Study (CHARLS).
Guosong Jiang, Licheng Feng, Xiaoxiao Qu, Jia Wang, Yun Li
{"title":"Inverted L-shape association between a body shape index and peak expiratory flow among middle-aged and older adults: findings from the China Health and Retirement Longitudinal Study (CHARLS).","authors":"Guosong Jiang, Licheng Feng, Xiaoxiao Qu, Jia Wang, Yun Li","doi":"10.1186/s12944-025-02599-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Peak expiratory flow (PEF) serves as a direct indicator of the functional status of the respiratory system. Higher body fat content, especially abdominal obesity, may relate to a deterioration in long-term respiratory function. The \"A Body Shape Index\" (ABSI) better assesses abdominal obesity, but its association with PEF is poorly understood.</p><p><strong>Methods: </strong>The analysis demonstrated data from 14,386 middle-aged and older adults from the 2015 China Health and Retirement Longitudinal Study (CHARLS). ABSI, a sex-specific metric integrating waist circumference, weight, and height via allometric modeling derived from Chinese anthropometrics, was analyzed against PEF/PEF <sub>prediction</sub> using multivariable linear and spline regressions to characterize nonlinear associations. Threshold effects, subgroup, and sensitivity analyses ensured robustness.</p><p><strong>Results: </strong>This research showed a negative relationship between ABSI and both PEF and PEF <sub>predictions</sub>. An inverted L-shaped curve in the spline analysis characterized the association between ABSI and PEF/PEF <sub>prediction</sub> across the sexes. The ABSI threshold was 0.0782 and 0.0691 in males and females, respectively.</p><p><strong>Conclusions: </strong>Abdominal obesity negatively affects respiratory function, with ABSI thresholds varying by sex. Therefore, weight management should focus on a healthy ABSI to reduce abdominal obesity and safeguard respiratory health.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"181"},"PeriodicalIF":3.9000,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084908/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-025-02599-2","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Peak expiratory flow (PEF) serves as a direct indicator of the functional status of the respiratory system. Higher body fat content, especially abdominal obesity, may relate to a deterioration in long-term respiratory function. The "A Body Shape Index" (ABSI) better assesses abdominal obesity, but its association with PEF is poorly understood.
Methods: The analysis demonstrated data from 14,386 middle-aged and older adults from the 2015 China Health and Retirement Longitudinal Study (CHARLS). ABSI, a sex-specific metric integrating waist circumference, weight, and height via allometric modeling derived from Chinese anthropometrics, was analyzed against PEF/PEF prediction using multivariable linear and spline regressions to characterize nonlinear associations. Threshold effects, subgroup, and sensitivity analyses ensured robustness.
Results: This research showed a negative relationship between ABSI and both PEF and PEF predictions. An inverted L-shaped curve in the spline analysis characterized the association between ABSI and PEF/PEF prediction across the sexes. The ABSI threshold was 0.0782 and 0.0691 in males and females, respectively.
Conclusions: Abdominal obesity negatively affects respiratory function, with ABSI thresholds varying by sex. Therefore, weight management should focus on a healthy ABSI to reduce abdominal obesity and safeguard respiratory health.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
