Time to positive blood cultures in neonatal sepsis evaluations.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-05-17 DOI:10.1038/s41372-025-02323-z

Emily Willey, Michelle Mitchell, Carey Ehlert, Jacob Swoveland, Tracy Zembles

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引用次数: 0

Abstract

Objective: This study evaluates the time to blood culture positivity among neonates evaluated for sepsis to determine when antibiotics may be safely discontinued.

Study design: Retrospective review of clinically relevant blood culture time to positivity from infants in a neonatal intensive care unit. The primary endpoint was overall median time to blood culture positivity. Secondary endpoints compared time to positivity among gram-positive versus gram-negative organisms, early versus late onset sepsis, and a sub-analysis excluding contaminants.

Result: Among 151 cultures, the overall median time to positivity was 17 h (IQR 12-23). Most (47/48, 97.9%) gram-negative organisms resulted within 24 h and most (88/94, 93.6%) gram-positive by 36 h. All (13/13, 100%) early onset cultures resulted within 24 h and most (132/138, 95.7%) late onset by 36 h.

Conclusion: Antibiotics for neonatal sepsis evaluation may be safely discontinued in well-appearing infants without an identified infection source with negative cultures at 36 h.

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新生儿败血症评估中血培养阳性的时间。

目的：本研究评估新生儿脓毒症的血培养阳性时间，以确定何时可以安全停用抗生素。研究设计：回顾性评价新生儿重症监护病房中与临床相关的血液培养时间到阳性的婴儿。主要终点是达到血培养阳性的总中位时间。次要终点比较革兰氏阳性与革兰氏阴性菌的阳性时间，早期与晚发败血症，以及排除污染物的亚分析。结果：151例培养中，总体中位阳性时间为17 h （IQR 12-23）。大多数革兰氏阴性菌（47/48,97.9%）在24 h内检出，大多数革兰氏阳性菌（88/94,93.6%）在36 h内检出。所有（13/13,100%）早发培养在24小时内发生，大多数（132/138,95.7%）晚发36小时。结论：用于新生儿脓毒症评估的抗生素可以在36小时内安全停用，这些婴儿没有确定的感染源，培养阴性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.