Effects of exercise on balance function in people with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-05-18 DOI:10.1007/s00415-025-13129-6

Yifan Zhang, Gen Li, Hao Su, Yin Liang, Yuanyuan Lv, Laikang Yu

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引用次数: 0

Abstract

Objective: This systematic review and meta-analysis aimed to evaluate the effect of exercise on balance function in multiple sclerosis (MS) patients and identify the optimal exercise prescription for this population.

Methods: A comprehensive search was conducted across PubMed, Web of Science, EBSCO, Cochrane, and Scopus up to February 21, 2025. The data were pooled using weighted mean differences (WMD) and 95% confidence interval.

Results: Fifty-two studies fulfilled the inclusion criteria. Exercise significantly improved Berg balance scale (BBS; WMD, 4.03; p < 0.00001) and timed up and go test (TUG; WMD, -1.01; p < 0.00001) in MS patients. The subgroup analyses revealed that resistance exercise (WMD, 6.07; p = 0.004), interventions lasting ≥ 8 weeks (WMD, 4.24; p < 0.00001), ≥ 3 times per week (WMD, 4.57; p < 0.00001), ≥ 60 min per session (WMD, 4.36; p < 0.00001), ≥ 180 min per week (WMD, 4.41; p < 0.00001) were most effective in improving BBS. Greater improvements were observed in patients aged < 45 years (WMD, 4.57; p < 0.00001) and those with baseline EDSS > 3.5 (WMD, 3.97; p < 0.00001).

Conclusions: Exercise was found to improve balance in MS patients. Our results suggest that MS patients may benefit from engaging in exercise sessions at least three times per week, with each session lasting 60 min or more, for a minimum duration of 8 weeks. Achieving a weekly exercise goal of 180 min or more may further enhance balance function.

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运动对多发性硬化症患者平衡功能的影响：随机对照试验的系统回顾和荟萃分析。

目的：本系统综述和荟萃分析旨在评估运动对多发性硬化症（MS）患者平衡功能的影响，并确定适合该人群的最佳运动处方。方法：综合检索PubMed， Web of Science， EBSCO， Cochrane和Scopus，截止到2025年2月21日。数据采用加权平均差（WMD）和95%置信区间合并。结果：52项研究符合纳入标准。运动显著改善Berg平衡量表（BBS）；大规模杀伤性武器,4.03;p 3.5 (WMD, 3.97；结论：运动可以改善MS患者的平衡能力。我们的研究结果表明，MS患者每周至少进行三次锻炼，每次持续60分钟或更长时间，至少持续8周，可能会受益。达到每周180分钟或更长时间的运动目标可以进一步增强平衡功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.