The diagnostic value of microrna-499 in acute myocardial infarction: A systematic review and meta-analysis.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-03-21 DOI:10.5937/jomb0-52617

Hong Du, Zhiyuan Zhang, Feifei Yan, Zichao Dong

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引用次数: 0

Abstract

Background: The objective of this study was to assess the diagnostic efficacy of MicroRNA-499 in cases of acute myocardial infarction.

Methods: On May 6, 2023, four electronic databases PubMed, Embase, Web of Science, and Cochrane Library were searched with no time restriction. Quality assessment was conducted using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Random-effects metaanalysis was employed to combine sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). The evaluation of publication bias was conducted through the utilization of Deeks' asymmetry test on the funnel plot.

Results: The studies that were included in the analysis, encompassing sample sizes ranging from 63 to 1155, exhibited a pooled sensitivity of 0.88 and a specificity of 0.97. The pooled PLR was determined to be 29.78, while the NLRwas found to be 0.13. Furthermore, the pooled DOR was calculated to be 236.10. The area under the curve (AUC) was reported as 0.98.

Conclusions: MicroRNA-499 exhibits high sensitivity and specificity for diagnosing Acute Myocardial Infarction, indicating its potential as a valuable diagnostic biomarker.

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microrna-499在急性心肌梗死中的诊断价值：系统回顾和荟萃分析。

背景：本研究的目的是评估MicroRNA-499在急性心肌梗死病例中的诊断效果。方法：于2023年5月6日无时间限制检索PubMed、Embase、Web of Science、Cochrane Library 4个电子数据库。使用诊断准确性研究质量评估-2 （QUADAS-2）进行质量评估。采用随机效应荟萃分析，综合敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）和诊断优势比（DOR）。发表偏倚评价采用漏斗图上的Deeks不对称检验。结果：纳入分析的研究，包括从63到1155的样本量，显示出0.88的综合敏感性和0.97的特异性。合并PLR为29.78，nlr为0.13。此外，池化的DOR被计算为236.10。曲线下面积（AUC）为0.98。结论：MicroRNA-499在诊断急性心肌梗死方面具有较高的敏感性和特异性，具有作为一种有价值的诊断生物标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.