Predictive value of pre-delivery serum b-human chorionic gonadotropin, fibrinogen, and homocysteine for pregnancy-induced hypertension.

Abstract

Background: We aimed to investigate the relationship between pre-delivery serum b-human chorionic gonado - tropin (b-HCG), fibrinogen (FIB), and homocysteine (HCY) with hypertensive disorder complicating pregnancy (HDCP).

Methods: This was a case-control study. 200 HDCP patients and 150 normal pregnant women were selected as study subjects. Fasting cubital venous blood samples were collected to measure serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and lowdensity lipoprotein (LDL), as well as b-HCG, FIB, and HCY levels. Pearson correlation analysis examined the relationship between b-HCG, FIB, HCY, and HDCP. Receiver operating characteristic (ROC) curve analysis evaluated the predictive value of these indicators for HDCP. Multiple logistic regression analysis identified risk factors (RFs) for HDCP.

Results: Serum TG, TC, HDL, LDL, FIB, b-HCG, and HCY were greatly elevated in the HDCP group versus the control group (CG) (P<0.05). Serum b-HCG, FIB, and HCY showed notable positive correlations with HDCP (r=0.935, 0.547, 0.811; P<0.05), and the areas under the ROC curve (AUC) for predicting HDCP based on serum b-HCG, FIB, HCY, and their combination were 0.743, 0.659, 0.801, and 0.886, respectively (P<0.05). Lipid indicators and serum levels of FIB, b-HCG, and HCY were RFs for HDCP.

Conclusions: Pregnant women with HDCP exhibited markedly elevated serum lipid levels and FIB, b-HCG, and HCY levels before delivery, which can serve as predictive indicators for HDCP.