{"title":"Effect of glycemic gap on prognosis and complications in vulnerable period of acute heart failure.","authors":"Lin Zheng, Weifeng Zheng, Mingming Zhang, Bo Li","doi":"10.5937/jomb0-52619","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To investigate the effect of glycemic gap on the prognosis and complications of heart failure in patients with acute heart failure.</p><p><strong>Methods: </strong>A total of 100 patients with acute heart failure admitted to our hospital from January 2022 to August 2023 were retrospectively selected, and the patients were divided into two groups according to their prognosis, the good prognosis group (n=58) and the poor prognosis group (n=42). The general data of the two groups were compared, and the influencing factors on the prognosis of patients with acute heart failure during the fragile period were analyzed by multi-factor Logistics regression. ROC analyzed the predictive value of blood sugar gap on the prognosis of acute heart failure patients during the vulnerable period of heart failure, and compared the incidence of complications between the two groups of patients..</p><p><strong>Results: </strong>The blood glucose gap, NT-proBNP, Ang II, hscTn, and SCR in patients with good prognosis were lower than those in patients with poor prognosis, and LVEF and hemoglobin were higher than those in patients with poor prognosis (P<0.05). Multivariate Logistics regression analysis results showed that blood glucose gap, NTproBNP, AngII, hs-cTn, SCR, LVEF, and hemoglobin were independent influencing factors on the prognosis of acute heart failure patients during the vulnerable period of heart failure (P<0.05), ROC analysis results showed that the area under the curve of the value of blood sugar gap in the prognosis of acute heart failure patients during the vulnerable period of heart failure was 0.6071,(95% CI: 0.3107~0.9035), Youden=0.89, at this time, the sensitiv ity was 92.8 and the specificity was 97.1. The complication rate in the good prognosis group (1.72%) was significantly lower than that in the poor prognosis group (16.67%).</p><p><strong>Conclusions: </strong>Glycemic gap is related to the prognosis and complications of heart failure in patients with acute heart failure. Hyperglycemia gap will affect the prognosis of heart failure in patients with acute heart failure, resulting in poor prognosis and increasing the incidence of complications.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"221-225"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085173/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Biochemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5937/jomb0-52619","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
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Abstract
Background: To investigate the effect of glycemic gap on the prognosis and complications of heart failure in patients with acute heart failure.
Methods: A total of 100 patients with acute heart failure admitted to our hospital from January 2022 to August 2023 were retrospectively selected, and the patients were divided into two groups according to their prognosis, the good prognosis group (n=58) and the poor prognosis group (n=42). The general data of the two groups were compared, and the influencing factors on the prognosis of patients with acute heart failure during the fragile period were analyzed by multi-factor Logistics regression. ROC analyzed the predictive value of blood sugar gap on the prognosis of acute heart failure patients during the vulnerable period of heart failure, and compared the incidence of complications between the two groups of patients..
Results: The blood glucose gap, NT-proBNP, Ang II, hscTn, and SCR in patients with good prognosis were lower than those in patients with poor prognosis, and LVEF and hemoglobin were higher than those in patients with poor prognosis (P<0.05). Multivariate Logistics regression analysis results showed that blood glucose gap, NTproBNP, AngII, hs-cTn, SCR, LVEF, and hemoglobin were independent influencing factors on the prognosis of acute heart failure patients during the vulnerable period of heart failure (P<0.05), ROC analysis results showed that the area under the curve of the value of blood sugar gap in the prognosis of acute heart failure patients during the vulnerable period of heart failure was 0.6071,(95% CI: 0.3107~0.9035), Youden=0.89, at this time, the sensitiv ity was 92.8 and the specificity was 97.1. The complication rate in the good prognosis group (1.72%) was significantly lower than that in the poor prognosis group (16.67%).
Conclusions: Glycemic gap is related to the prognosis and complications of heart failure in patients with acute heart failure. Hyperglycemia gap will affect the prognosis of heart failure in patients with acute heart failure, resulting in poor prognosis and increasing the incidence of complications.
期刊介绍：
The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
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clinical hematology and coagulation,
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genetic epidemiology,
drug measurement,
evaluation of diagnostic markers,
new reagents and laboratory equipment,
reference materials and methods,
reference values,
laboratory organization,
automation,
quality control,
clinical metrology,
all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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