Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy.

IF 10.6 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Nanobiotechnology Pub Date : 2025-05-17 DOI:10.1186/s12951-025-03378-y

Hao Zheng, Yiquan Chen, Wei Luo, Shiqi Han, Mengjuan Sun, Min Lin, Chenghan Wu, Lili Gao, Tian Xie, Na Kong

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Abstract

Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune responses to control and eliminate tumors effectively. The active ingredients of traditional Chinese medicine (TCM) demonstrate a variety of anti-tumor activities and mechanisms, including the modulation of immune cell functions and inhibiting tumor-related suppressive factors, thereby potentially enhancing anti-tumor immune responses. Furthermore, nano-delivery systems function as efficient carriers to enhance the bioavailability and targeted delivery of TCM active ingredients, augmenting therapeutic efficacy. This review comprehensively analyzes the impact of TCM active ingredients on the immune system and explores the synergistic application of nano-delivery systems in combination with TCM active ingredients for enhancing tumor immunotherapy.

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中药有效成分与纳米递送系统的结合用于肿瘤免疫治疗。

肿瘤免疫逃逸是肿瘤治疗中的一个重大挑战，其特征是免疫抑制分子上调和免疫细胞功能障碍。肿瘤免疫治疗旨在恢复正常的抗肿瘤免疫反应，从而有效地控制和消除肿瘤。中药有效成分具有多种抗肿瘤活性和机制，包括调节免疫细胞功能和抑制肿瘤相关抑制因子，从而潜在地增强抗肿瘤免疫反应。此外，纳米递送系统作为有效的载体，可以提高中药有效成分的生物利用度和靶向递送，提高治疗效果。本文综合分析了中药有效成分对免疫系统的影响，并探讨了纳米递送系统与中药有效成分联合在增强肿瘤免疫治疗中的协同应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nanobiotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

13.90

自引率

4.90%

发文量

493

审稿时长

16 weeks

期刊介绍： Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.