Effects of use of metformin or combination of metformin and pioglitazone on oxidative stress in type 2 diabetes mellitus.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-03-21 DOI:10.5937/jomb0-50062

Temiz Gençoğlu Ayşe Tuğçenur, Kalkan Emra Asfuroğlu, Oğuzhan Zengin, Özcan Erel, İhsan Ateş

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引用次数: 0

Abstract

Background: We aimed to examine how oxidative stress changes after treatment and its relationship with metabolic parameters in patients diagnosed with Type 2 Diabetes Mellitus treated with metformin alone or with a combination of metformin and pioglitazone.

Methods: The study population consisted of a total of 60 patients, including the group diagnosed with Type 2 Diabetes Mellitus (T2DM) who received metformin 2x1000 mg (n=30) and the other group who received metformin with pioglitazone 2x15/1000 mg (n=30). Serum IMA (ischemia-modified albumin), TAS (total antioxidant status), TOS (total oxidant status) and thiol-disulphide homeostasis were measured before and after 12 weeks of treatment.

Results: No significant change was detected in Native sulfhydryl (SH) and Total SH levels in both Metformin and combination groups. IMA levels increased significantly in both drug groups (p=0.03 and p=0.01, respectively). Although the TAS level increased in both groups, no significant change was detected. While the TOS and oxidative stress index (OSI) index decreased significantly in the combination group (p<0.001), the decrease in the metformin group was not significant. No significant difference was detected between Native SH, Total SH, Disulfide, IMA, TAS, TOS levels and OSI index changes of both drug groups.

Conclusions: We found that the use of anti-diabetic drugs did not have a significant effect on oxidative stress.

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二甲双胍或二甲双胍与吡格列酮联用对2型糖尿病氧化应激的影响

背景：我们旨在研究诊断为2型糖尿病的患者单用二甲双胍或联用二甲双胍和吡格列酮治疗后氧化应激的变化及其与代谢参数的关系。方法：研究人群共60例患者，其中诊断为2型糖尿病（T2DM）组接受二甲双胍2x1000 mg治疗（n=30），另一组接受二甲双胍与吡格列酮2x15/1000 mg治疗（n=30）。治疗12周前后测定血清缺血修饰白蛋白（IMA）、总抗氧化状态（TAS）、总氧化状态（TOS）和二硫醇稳态。结果：二甲双胍组和联合用药组血清SH和总SH水平无明显变化。两组IMA水平均显著升高（p=0.03和p=0.01）。两组TAS水平均升高，但未见明显变化。而联合用药组的TOS和氧化应激指数（OSI）指数明显下降(p)。结论：我们发现抗糖尿病药物的使用对氧化应激无显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.