Adoption value of serum hematological inflammatory markers in early diagnosis of necrotising enterocolitis.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2025-03-21 DOI:10.5937/jomb2502244L

Ruogu Luo, Jing Zhang, Xiaolong Li, Fei Peng, Anpeng Zhang, Pengfei Zhang

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引用次数: 0

Abstract

Background: Early diagnosis and intervention of neonatal necrotising enterocolitis (NEC) are crucial for improving prognosis. It was to assess the diagnostic and staging value of high-sensitivity C-reactive protein (hs-CRP), white blood cell count (WBC), and interleukin (IL)-6 levels in NEC, and to explore their correlation with disease severity.

Methods: This retrospective study analysed clinical data from 43 NEC patients in the neonatology department of Northwest Women and Children's Hospital, designated as the experimental group (EG), and concurrently selected 38 healthy newborns as the control group (CG). Serum hsCRP, WBC, and IL-6 were measured in both groups. Statistical analyses were performed using SPSS 27.0.

Results: hs-CRP, WBC, and IL-6 in NEC patients greatly surpassed those in healthy newborns, and these markers were notably positively correlated with NEC staging (r=0.756, 0.234, 0.901, P<0.05). Combined detection of hs-CRP, WBC, and IL-6 in early NEC diagnosis yielded an AUC of 0.988, with a sensitivity of 93.02% and specificity of 97.37%, all superior to individual detections (P<0.05).

Conclusions: hs-CRP, WBC, and IL-6 are essential in diagnosing and assessing NEC, particularly combined detection, which greatly improves early diagnostic accuracy. Future research should further investigate additional inflammatory markers to optimise diagnostic methods, providing a more comprehensive scientific basis for early clinical intervention and treatment.

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血清血液学炎症标志物在坏死性小肠结肠炎早期诊断中的应用价值。

背景：新生儿坏死性小肠结肠炎（NEC）的早期诊断和干预对改善预后至关重要。目的探讨高敏c反应蛋白（hs-CRP）、白细胞计数（WBC）、白细胞介素(IL)-6水平在NEC中的诊断和分期价值，并探讨其与疾病严重程度的相关性。方法：回顾性分析西北妇幼医院新生儿科43例NEC患者的临床资料，作为实验组（EG），同时选取38例健康新生儿作为对照组（CG）。检测两组患者血清hsCRP、WBC、IL-6。采用SPSS 27.0进行统计学分析。结果：NEC患者hs-CRP、WBC、IL-6显著高于健康新生儿，且这些指标与NEC分期呈显著正相关（r=0.756、0.234、0.901）。结论：hs-CRP、WBC、IL-6对NEC的诊断和评估至关重要，尤其是联合检测，大大提高了早期诊断的准确性。未来的研究应进一步探索其他炎症标志物，优化诊断方法，为临床早期干预和治疗提供更全面的科学依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.