Dopamine and Mn(II) Chelate Covalent-Doping Coated Ti(IV)-Nanotheranostics for Magnetic Resonance Imaging Guided Phototherapy in Oral Cancer.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S512565

Zhenghui Li, Xufei Bian, Huiyu Wu, Ling He, Zuhua Zeng, Lei Zhong, Yao Liu, Yu Li, Guihao Hu, Fanglin Mi, Zhen Liu, Jiang Zhu

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引用次数: 0

Abstract

Purpose: Phototherapy have gained significant traction in the treatment of tumors. However, the successful implementation of these therapies relies on photosensitizers with superior properties and precise guidance mechanisms.

Methods: In this study, we introduce an innovative method for the surface modification of titanium dioxide (TiO₂) nanoparticles through HRP-catalyzed covalent incorporation of Mn(II) chelate (Mn-Dopa) and dopamine.

Results: This modification extends TiO₂ nanoparticels' light absorption from ultraviolet to the near-infrared (NIR) range, endowing the nanoparticles with MRI-guided phototherapy capabilities. The resulting nanotheranostics system, TiO₂@PDA-MnDopa, demonstrated over 5-fold enhanced relaxivity compared to the monomeric MnDopa and exhibited synergistic phototherapy effects upon 808 nm laser excitation, with a photothermal conversion efficiency of 15.91%. In vitro and in vivo pharmacodynamics studies showed that the TiO₂@PDA-MnDopa demonstrated good safety in the HSC3 cell line and corresponding tumor-bearing mice, while effectively inhibiting tumor growth under 808 nm laser excitation.

Conclusion: This multifunctional nanotheranostic, integrating high relaxivity with synergistic PTT/PDT for MR imaging-guided phototherapy, holds great potential for applications in the early diagnosis, noninvasive treatment, and prognostic evaluation of oral squamous cell carcinoma.

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多巴胺和Mn（II）螯合共价掺杂包覆Ti（IV）纳米治疗在口腔癌磁共振成像引导光疗中的应用。

目的：光疗在肿瘤治疗中具有重要的应用价值。然而，这些疗法的成功实施依赖于具有优越性能的光敏剂和精确的引导机制。方法：在这项研究中，我们介绍了一种创新的方法，通过酶催化Mn（II）螯合物（Mn- dopa）和多巴胺的共价结合，对二氧化钛（TiO2）纳米颗粒进行表面改性。结果：该修饰将TiO2纳米粒子的光吸收范围从紫外光扩展到近红外（NIR）范围，使纳米粒子具有mri引导的光疗能力。所制备的纳米治疗体系TiO2@PDA-MnDopa与MnDopa单体相比，其弛豫度增强了5倍以上，在808 nm激光激发下表现出协同光疗效果，光热转换效率为15.91%。体外和体内药效学研究表明，TiO2@PDA-MnDopa在808 nm激光激发下对HSC3细胞系和相应的荷瘤小鼠具有良好的安全性，同时能有效抑制肿瘤生长。结论：该多功能纳米治疗方法将高弛弛性与协同PTT/PDT相结合，用于MR成像引导下的光疗，在口腔鳞状细胞癌的早期诊断、无创治疗和预后评估方面具有很大的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.