Short-term bactericidal properties differ between 2 alcohol-based surgical antiseptic products using the glove-juice technique.

IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES
Katrijn D Whisenant, Holly L Stewart, Donna Kelly, Denise Barnhart, Valerie Rossney, Dean W Richardson, David Levine
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引用次数: 0

Abstract

Objective: To evaluate the efficacy of 2 alcohol-based hand preparations (61% weight/weight ethanol and 1% chlorhexidine gluconate [Avagard; 3M] and 85% weight/weight ethanol [Sterillium; BODE Chemie GmbH]) in reducing bacterial colony count with the glove-juice method. We hypothesized that there would be no difference between hand preparations immediately following or 1 hour after application.

Methods: A prospective clinical trial was performed with sampling on August 3, 2023. Preliminary CFUs were obtained from both hands of 8 participants via glove-juice sampling from sterile gloves. Participants washed their hands with a neutral soap before the application of any antiseptics. Avagard was applied to the right hand and Sterillium was applied to the left hand by sterile assistants according to the manufacturer's guidelines. Glove-juice samples were taken immediately after application and 1 hour after application. Samples were cultured and evaluated within 48 hours of plating. Log10-reduction CFUs were compared between antiseptics and across time points.

Results: Results were based on 7 participants due to a missing time point. Both Sterillium and Avagard showed a reduction in CFUs immediately after application. For Avagard, there was a sustained reduction in CFUs at 1 hour after application.

Conclusions: Both hand preparations were effective antiseptics immediately following application. Avagard was effective at reducing bacterial CFUs 1 hour after application.

Clinical relevance: Unless for reapplication, only Avagard should be considered if surgery is expected to be longer than 1 hour or reapplication of Sterillium is recommended.

使用手套汁技术的两种基于酒精的手术抗菌产品的短期杀菌性能不同。
目的:评价2种醇基手制剂(61%重量/重量乙醇和1%葡萄糖酸氯己定)的疗效。和85%重量/重量乙醇[Sterillium;博德化学有限公司[BODE Chemie GmbH])用手套汁法减少细菌菌落计数。我们假设在应用后1小时或立即使用手制剂之间没有差异。方法:于2023年8月3日抽样进行前瞻性临床试验。通过无菌手套的手套汁取样,从8名参与者的双手获得初步CFUs。在使用任何防腐剂之前,参与者用中性肥皂洗手。根据制造商的指导方针,Avagard应用于右手,Sterillium应用于左手。应用后立即和应用后1小时采集手套汁样品。样品在电镀后48小时内进行培养和评估。比较了不同防腐剂和不同时间点的Log10-reduction cfu。结果:由于时间点缺失,结果基于7名参与者。Sterillium和Avagard在施用后立即显示cfu减少。对于Avagard,应用后1小时cfu持续降低。结论:两种手部制剂在使用后均为有效的防腐剂。Avagard在使用后1小时有效降低细菌cfu。临床相关性:除非需要重新应用,如果手术时间预计超过1小时或建议重新应用Sterillium,则只应考虑使用Avagard。
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来源期刊
CiteScore
1.60
自引率
15.80%
发文量
539
审稿时长
6-16 weeks
期刊介绍: Published twice monthly, this peer-reviewed, general scientific journal provides reports of clinical research, feature articles and regular columns of interest to veterinarians in private and public practice. The News and Classified Ad sections are posted online 10 days to two weeks before they are delivered in print.
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