The effects of music and darkness on radionuclide distribution during mice FDG-PET scan.

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Iranian journal of veterinary research Pub Date : 2025-01-01 DOI:10.22099/ijvr.2024.49641.7306

K Tanha, M Seyedabadi, H Ghadiri, M Ay

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引用次数: 0

Abstract

Background: There is growing interest in the therapeutic potential of music or light in different human disorders.

Aims: This study aimed to evaluate the effects of music as well as darkness on FDG uptake in 4T1 tumor-bearing BALB/c mice using a PET scan.

Methods: The music, darkness, and music plus darkness groups were subjected to either song or darkness and their combination, respectively, 30 min before the radiopharmaceutical injection until the end of the experiments. The control group was imaged in silence under ambient conditions.

Results: Our results revealed that music did not significantly alter the range of tumor SUVmean, but showed a slight increase in brain SUVmean (18.2%) and about 100% increase in brain percentage of injected dose per gram (%ID/g) in ex vivo analysis. In contrast, heart SUVmean and heart %ID/g were approximately half those of the silence group. The muscle SUVmean and blood activity measurements showed a decrement upon music exposure. Also, results showed a significant difference in tumor-to-muscle ratio (85% increment) and brain-to-muscle ratio (105% increment) between the silence and music groups. The muscle SUVmean decreased by 50%, and tumor-to-muscle and brain-to-muscle ratios were observed to increase by 44% and 60% in the group exposed to darkness, respectively.

Conclusion: Our results suggest that music and environmental factors may influence FDG uptake in small-animal PET imaging, and provide important insights into the reliability of FDG-PET imaging for music intervention research and may aid researchers in investigating the effects of music on brain changes and tissue metabolism.

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音乐和黑暗对小鼠FDG-PET扫描过程中放射性核素分布的影响。

背景：人们对音乐或光线在不同人类疾病中的治疗潜力越来越感兴趣。目的：本研究旨在通过PET扫描评估音乐和黑暗对4T1荷瘤BALB/c小鼠FDG摄取的影响。方法：音乐组、黑暗组、音乐加黑暗组分别在放射药物注射前30 min进行歌曲或黑暗及其组合，直至实验结束。对照组在环境条件下沉默成像。结果：我们的研究结果显示，音乐没有显著改变肿瘤的SUVmean范围，但在离体分析中显示，脑SUVmean略有增加（18.2%），每克注射剂量的脑百分比（%ID/g）增加约100%。相比之下，心脏SUVmean和心脏%ID/g约为沉默组的一半。肌肉SUVmean和血液活动测量显示，音乐暴露后，肌肉萎缩。此外，结果显示，在沉默组和音乐组之间，肿瘤与肌肉的比例（增加85%）和脑与肌肉的比例（增加105%）存在显著差异。肌肉SUVmean下降了50%，在黑暗环境下，肿瘤与肌肉和脑与肌肉的比例分别增加了44%和60%。结论：我们的研究结果表明，音乐和环境因素可能影响小动物PET成像中FDG的摄取，为FDG-PET成像在音乐干预研究中的可靠性提供了重要的见解，并可能有助于研究音乐对大脑变化和组织代谢的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

8.30%

发文量

期刊介绍： The Iranian Journal of Veterinary Research(IJVR) is published quarterly in 4 issues. The aims of this journal are to improve and expand knowledge in all veterinary fields. It is an international journal indexed by the Thomson Institute for Scientific Information (ISI), Elsevier, Scopus, CAB International, Veterinary Bulletin and several other international databases. Research papers and reports on a wide range of veterinary topics are published in the journal after being evaluated by expert reviewers.The Editor-in-Chief is responsible for the editorial content of the journal—including peer-reviewed manuscripts—and the timing of its publication.