Mendelian Randomization Analyses Explore the Relationship between Trace Elements and Prostate Cancer.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-05-01 DOI:10.7754/Clin.Lab.2024.241010

Cheng-Hao Zhou, Huai-Lan Wang, Chen-Hao Yu, Gong-Hui Li

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引用次数: 0

Abstract

Background: Trace elements indeed play a significant role in the occurrence and development of cancers, but it remains ambiguous whether a causal relationship exists between trace elements and prostate cancer. This study employed Mendelian randomization analyses to investigate such a causal link between trace elements (Co, Fe, Mg, Se, and Zn) and prostate cancer.

Methods: The analyses primarily utilized the inverse variance weighted (IVW) method, supplemented by MR-Egger, weighted median, simple mode, and MR-PRESSO.

Results: The results of IVW (OR = 1.005, 95% CI: 1.001 - 1.009, p = 0.014) and MR-PRESSO (OR = 1.005, 95% CI: 1.002 - 1.008, p = 0.015) analyses demonstrated a significant causal effect of Mg on genetically predicted prostate cancer. However, the IVW analysis did not reveal any causal associations between prostate cancer and Co, Fe, Se, or Zn.

Conclusions: Our study provided compelling evidence of a causal relationship between magnesium and prostate cancer within the European population. Therefore, maintaining magnesium balance may emerge as a potent strategy for prostate cancer prevention.

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孟德尔随机化分析探讨微量元素与前列腺癌的关系。

背景：微量元素确实在癌症的发生发展中起着重要作用，但微量元素与前列腺癌之间是否存在因果关系尚不明确。本研究采用孟德尔随机分析来研究微量元素（Co, Fe, Mg， Se和Zn）与前列腺癌之间的因果关系。方法：以方差反加权（IVW）法为主，辅以MR-Egger法、加权中位数法、简单模式法和MR-PRESSO法。结果：IVW （OR = 1.005, 95% CI: 1.001 - 1.009, p = 0.014）和MR-PRESSO （OR = 1.005, 95% CI: 1.002 - 1.008, p = 0.015）分析结果显示Mg对基因预测的前列腺癌有显著的因果关系。然而，IVW分析并没有揭示前列腺癌与Co、Fe、Se或Zn之间的任何因果关系。结论：我们的研究为欧洲人群中镁和前列腺癌之间的因果关系提供了令人信服的证据。因此，维持镁平衡可能成为预防前列腺癌的有效策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.