Ganoderma lucidum extract reduces skin aging by reducing mitochondrial stress and controlling mitochondrial numbers

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-05-15 DOI:10.1016/j.fitote.2025.106627

Han Wang , Meiling Tai , Wanzhao Li , Yawen Li , Zhimeng Zhang , Dongli Zhang , Lishe Gan , Junhao Li , Xiaojuan Song , Honghong Qiu , Manmei Li , Heyun Zhang , Zhong Liu

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Abstract

Mitochondrial dysfunction is one of the important signs of cellular and even individual aging. Ganoderma lucidum is a common edible and medicinal mushroom, widely used as a functional food in Asia. This study investigated the potential anti-aging effects of Ganoderma lucidum extract (GLE). Our results demonstrated that GLE alleviated cellular oxidative stress, reduced the abnormal increase of mitochondrial ROS in aging cells, and maintained mitochondrial membrane integrity and inner membrane potential. Additionally, GLE affected mitochondrial biogenesis in aging cells. In a murine photoaging model, GLE treatment mitigated UVA-induced mitochondrial dysfunction while markedly attenuating UVA-triggered epidermal thickening and dermal protein depletion. These properties may be interrelated with the presence of abundant triterpenoids identified by LC-MS analysis.

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灵芝提取物通过减少线粒体压力和控制线粒体数量来减少皮肤老化。

线粒体功能障碍是细胞甚至个体衰老的重要标志之一。灵芝（Ganoderma lucidum）是一种常见的食药用菌，在亚洲被广泛用作功能性食品。研究了灵芝提取物（Ganoderma lucidum extract， GLE）的潜在抗衰老作用。我们的研究结果表明，GLE减轻了细胞氧化应激，减少了衰老细胞中线粒体ROS的异常增加，维持了线粒体膜的完整性和内膜电位。此外，GLE影响衰老细胞的线粒体生物发生。在小鼠光老化模型中，GLE治疗减轻了uva诱导的线粒体功能障碍，同时显著减轻了uva引发的表皮增厚和真皮蛋白消耗。这些特性可能与LC-MS分析发现的丰富的三萜有关。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.