Antimicrobial efficacy of viridicatol derived from P. crustosum S14 against MRSA: Mechanistic insights from a comprehensive multi-omics analysis

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-05-15 DOI:10.1016/j.fitote.2025.106622

Jiwen Wang , Yajing He , Mengqun Liu , Hanxiang Jiang , Dong Feng , Xinna Liu , Junbiao Yang , Xuzhe Zhou , Zhilong An , Yuanyuan Lu , Xiaoqian Jia , Chun Ge , Ying Wang

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) presents a formidable challenge to public health, necessitating alternative strategies to address the superbug-related infections. This study systematically evaluates the antibacterial efficacy of Viridicatol, a compound isolated from the fermentation products of Penicillium crustosum derived from marine. Special emphasis was placed on its potent activity against MRSA USA300. Through a comprehensive suite of morphological, biophenotypic, genomic, and metabolomic analyses, we elucidate the mechanisms of action of this agent. Our findings reveal that Viridicatol exhibits significant bactericidal effects, primarily through the disruption of bacterial structural integrity and the induction of severe intracellular metabolic disturbances. These effects were further corroborated in an animal full-thickness wound infection model. Our study provides both a foundational understanding and mechanistic insight into Viridicatol, while also shedding light on the clinical control and management of MRSA.

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从壳皮菌S14提取的vi讥讽醇对MRSA的抗菌效果：来自综合多组学分析的机制见解。

耐甲氧西林金黄色葡萄球菌（MRSA）对公共卫生提出了巨大的挑战，需要替代策略来解决超级细菌相关感染。本研究系统地评价了从海洋发酵剂青霉发酵产物中分离得到的化合物vi讥讽醇的抑菌效果。特别强调了其对MRSA USA300的有效活性。通过一套全面的形态学、生物表型、基因组学和代谢组学分析，我们阐明了这种药物的作用机制。我们的研究结果表明vi讥讽醇具有显著的杀菌作用，主要是通过破坏细菌结构完整性和诱导严重的细胞内代谢紊乱。这些效果在动物全层伤口感染模型中得到进一步证实。我们的研究提供了对vi讥讽醇的基础理解和机制洞察，同时也为MRSA的临床控制和管理提供了启示。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.