Causal Effect of Residual Cholesterol on Psoriatic Arthritis: a Mendelian Randomization Study.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2025-05-01 DOI:10.7754/Clin.Lab.2025.250118

Wenying Long, Quan Miao

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引用次数: 0

Abstract

Background: Accumulating evidence suggests an intimate relationship between residual cholesterol and psoriatic arthritis (PsA). However, owing to confounding and reverse causality, this relationship remains unclear in observational studies. The aim of our study was to identify the causal relationship of residual cholesterol with PsA by Mendelian randomization.

Methods: In this study, we obtained genetic variants linked with residual cholesterol levels in the largest genome-wide association study (GWAS) on Europeans. We also selected genetic variants corresponding effect estimates on PsA risk from a large GWAS. To make the results more stable, we used six robust analytical methods for the MR analysis. The results of MR analyses in the discovery/validation set were combined using the fixed-effect model. Furthermore, we also used MR Steiger to assess the possible direction of causal estimate between them.

Results: In the discovery set, gene prediction found that for every 1 SD increase in residual cholesterol levels, the relative risk of PsA increased 1.177 (95% CI: 1.024 - 1.353). In the validation set, we observed that for every 1 SD increase in residual cholesterol levels, the relative risk of PsA increased 1.185 (95% CI: 1.068 - 1.316). In the meta-analysis, we found residual cholesterol levels could increase the risk of PsO. In addition, MR Steiger also found reverse causality between them.

Conclusions: This study supports evidence of a relationship of residual cholesterol with PsA.

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残留胆固醇对银屑病关节炎的因果影响：孟德尔随机研究。

背景：越来越多的证据表明残留胆固醇与银屑病关节炎（PsA）之间存在密切关系。然而，由于混杂和反向因果关系，这种关系在观察性研究中仍然不清楚。我们研究的目的是通过孟德尔随机化来确定残余胆固醇与PsA的因果关系。方法：在这项研究中，我们在欧洲最大的全基因组关联研究（GWAS）中获得了与残留胆固醇水平相关的遗传变异。我们还从一个大GWAS中选择了相应的遗传变异对PsA风险的影响估计。为了使结果更加稳定，我们使用了六种稳健的分析方法进行MR分析。发现/验证集中的MR分析结果使用固定效应模型进行组合。此外，我们还使用MR Steiger来评估它们之间因果估计的可能方向。结果：在发现集中，基因预测发现残留胆固醇水平每增加1 SD， PsA的相对危险度增加1.177 （95% CI: 1.024 - 1.353）。在验证集中，我们观察到残留胆固醇水平每增加1 SD， PsA的相对风险增加1.185 （95% CI: 1.068 - 1.316）。在荟萃分析中，我们发现残留胆固醇水平会增加患PsO的风险。此外，斯泰格还发现两者之间存在反向因果关系。结论：本研究支持残留胆固醇与PsA之间关系的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.