The Myriad Spectrum of Salivary Gland Lesions: Cytohistological Correlation on Fine Needle Aspiration Cytology, Core Needle Biopsy, and Resections in a 5-Year Single Institutional Experience of North India

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2025-05-19 DOI:10.1002/dc.25487

Zachariah Chowdhury, Pallavi Majumdar, Sumeet Narain, Komal Lamba

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引用次数: 0

Abstract

Introduction

Fine needle aspiration cytology (FNAC) is a cost-effective method used for preoperative diagnosis of salivary gland lesions. Due to the wide range of tumor types, overlapping morphology, and limited cellularity, diagnosing salivary gland lesions on FNAC can be challenging. A pattern-based approach focusing on cellular and architectural features possible on core needle biopsy (CNB) can help refine differential diagnoses.

Objectives

This study aimed to assess the concordance between FNAC and histological diagnoses obtained from CNB, as well as examine the risk of malignancy (ROM), and evaluate the agreement between histopathological assessments and diagnoses of these lesions in both CNB and resection specimens.

Materials and Methods

A retrospective observational study was conducted in the Department of Oncopathology at a tertiary cancer center of North India over a period of 5 years. Cases wherein diagnosis offered on two modalities—FNAC and CNB were—available, were included.

Results

A total of 105 cases were identified. Category VI was the predominant category (60.95%) and the ROM in categories II, III, and IV was higher compared to that mentioned in the Milan System for Reporting Salivary Gland Cytopathology. Correlation between FNAC and CNB was achieved in 78.1% of cases, and between CNB and the final diagnosis on resection specimen was attained in 100% of cases.

Conclusion

The limitations of FNAC can be obviated by the utilization of CNB. Ancillary studies such as immunohistochemistry and/or cytogenetics wherever necessary can be smoothly applied on biopsy material, establishing the precise diagnosis and thereby providing definitive direction to further management.

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唾液腺病变的无数谱：细针抽吸细胞学、核心针活检和北印度5年单一机构经验的细胞组织学相关性。

细针吸细胞学（FNAC）是一种成本效益高的方法，用于术前诊断唾液腺病变。由于肿瘤类型广泛，形态重叠，细胞有限，诊断FNAC上的唾液腺病变是具有挑战性的。基于模式的方法关注细胞和结构特征可能在核心针活检（CNB）可以帮助改进鉴别诊断。目的：本研究旨在评估FNAC与CNB的组织学诊断之间的一致性，以及检查恶性肿瘤（ROM）的风险，并评估CNB和切除标本中这些病变的组织病理学评估和诊断之间的一致性。材料和方法：在北印度某三级癌症中心的肿瘤病理科进行了一项为期5年的回顾性观察研究。病例诊断提供两种模式- fnac和CNB是可用的，包括。结果：共确诊105例。第VI类为主要类别（60.95%），第II、III和IV类的ROM高于米兰系统中唾液腺细胞病理学报告。FNAC与CNB的相关性为78.1%，CNB与切除标本最终诊断的相关性为100%。结论：CNB的应用可消除FNAC的局限性。辅助研究，如免疫组织化学和/或细胞遗传学，在必要时可以顺利地应用于活检材料，建立准确的诊断，从而为进一步的治疗提供明确的指导。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.